4.4 Article

Efficient access to multi-substituted 1-aminoisoquinolines via Rh(III)- catalyzed oxidative annulation of aminopyridine pivalamides with internal alkynes

Journal

TETRAHEDRON LETTERS
Volume 103, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2022.153970

Keywords

Rhodium; C-H activation; Annulation; Aminopyridine; Isoquinoline

Funding

  1. National Natural Science Foundation of China [21801023]
  2. Natural Science Foundation of Hunan Province [2019JJ50635]
  3. Huxiang High-Level Talent Gathering Project of Hunan Province [2018RS3076]
  4. Changsha Municipal Science and Technology Project [kq2004070]
  5. Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation [2021CL04]

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The synthesis of multi-substituted 1-aminoisoquinolines from aminopyridine pivalamides with alkynes by Rh(III)-catalyzed C-H activation coupling has been successfully achieved. This method is tolerant of various functional groups and provides moderate yields of highly substituted isoquinoline derivatives.
The synthesis of multi-substituted 1-aminoisoquinolines from aminopyridine pivalamides with alkynes by Rh(III)-catalyzed C-H activation coupling has been investigated. This method proved to be tolerant of synthetically versatile functional groups, and provided access to a few highly substituted isoquinoline derivatives with remarkable fluorescence properties in moderate yields.(c) 2022 Elsevier Ltd. All rights reserved.

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