Lewis base catalyzed allylation reaction of N-aryl amides with Morita-Baylis-Hillman carbonates

A Lewis base catalyzed allylation reaction of N-aryl amides with various Morita-Baylis-Hillman (MBH) carbonates was described. The substrate scope of MBH carbonates and amides were comprehensively explored. The broad substrate scope, mild condition, as well as scale-up synthesis made this approach useful for the synthesis of diverfied branched tertiary N-allylic amides. (c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

This article describes a Lewis base catalyzed allylation reaction between N-aryl amides and various Morita-Baylis-Hillman (MBH) carbonates. The substrate scope of MBH carbonates and amides is comprehensively explored, making this approach useful for the synthesis of diversified branched tertiary N-allylic amides, with broad substrate scope, mild reaction conditions, and scalability.