Journal
TETRAHEDRON
Volume 122, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2022.132937
Keywords
Picolinamides; Ritter reaction; Amidation; C -H Activation; Palladium
Categories
Ask authors/readers for more resources
The synthesis of picolinamides through Ritter reaction of 2-cyanopyridine with alcohols and alkenes is reported, and a range of additional heteroaryl nitriles successfully participate in the amidation reaction. The salient features of this reaction include operational simplicity and the use of inexpensive reagents. The synthetic utility of a camphene derived picolinamide is demonstrated through a palladium-catalyzed C-H arylation reaction.
The synthesis of picolinamides through Ritter reaction of 2-cyanopyridine with alcohols and alkenes is reported. Moreover, a range of additional heteroaryl nitriles successfully participate in the amidation reaction. Salient features of the reaction include the operational simplicity and the inexpensive reagents used. The synthetic utility of a camphene derived picolinamide is demonstrated through a palladium -catalyzed C-H arylation reaction. (c) 2022 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
