Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 34, Issue -, Pages 76-87Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jddst.2016.01.010
Keywords
Drug delivery; Glass capillary; Microfluidics; Single emulsion; Double emulsion; Multiple emulsion
Categories
Funding
- Academy of Finland [252215, 281300]
- University of Helsinki Research Funds
- Biocentrum Helsinki
- European Research Council under the European Union's Seventh Framework Programme (FP) [310892]
- Drug Research Doctoral Programme of the Faculty of Pharmacy, University of Helsinki
- Tekes large strategic research opening project [40395/13]
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The need for new and more advanced drug delivery systems (DDS) is currently in demand for efficient delivery of the therapeutics to the desirable tissues/cells, improved drug formulations, and industrial scale production. The newly developed drugs often present poor biopharmaceutical properties, therefore suffering from poor patient compliance, as well as deleterious side effects. Emulsion-based formulations gained attention as potential DDS for the delivery of single or combined small drug molecules with different physicochemical properties. However, the conventional fabrication methods often yield heterogeneous drug formulations. The microfluidics technique offers several advantages over conventional methods for the synthesis. of DDS. The highly monodisperse droplets obtained with this technique are useful templates in the preparation of several DDS, such as microcapsules, microspheres, polymersomes, and liposomes. In this review, we will discuss and provide an overview of the microfluidics techniques based on glass capillary as a tool for the fabrication of advanced DDS. In particular, we will focus on the production of droplet-based systems by single, double, and multiple emulsion microfluidic techniques. Finally, the future prospects and potentials of the microfluidics technique are also elucidated. (C) 2016 Elsevier B.V. All rights reserved.
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