Microwave-assisted intramolecular palladium-mediated cyclizations of o-iodobenzophenones for methoxy fluoren-9-ones

Microwave (MW) irradiation is an effective tool in organic reactions that required long reaction times under thermal conditions. Herein substituted 2-iodobenzophenones were transformed into substituted fluoren-9-ones via cesium carbonate and bis(triphenylphosphine) palladium(II) chloride with 56-92% yields within 30-45 min under microwave irradiations. A remarkable decrease in the reaction time with high yield products was observed. The isolated products have been emphasize on the basis of (H-1/(CNMR)-C-13) and correlations spectra.

Automated summary

Microwave irradiation is an effective tool for organic reactions, allowing for shorter reaction times and higher yields. In this study, substituted 2-iodobenzophenones were transformed into substituted fluoren-9-ones with yields of 56-92% using microwave irradiation.