A simple and efficient protocol for the synthesis of quinoxaline derivatives using recyclable H5PW6Mo4V2O40•14H2O catalyst

Vanadium substituted Molybdotungstophosphoric acid (H5PW6Mo4V2O40 center dot 14H(2)O) was observed to be an effective solid catalyst for one-pot synthesis of several quinoxaline derivatives from the condensation reaction between various substituted o-phenylenediamine and various aromatic benzil compounds in ethanol: water (1:1) solvent under the reflux condition. The catalytic activity was tested under different reaction conditions to know the performance of the synthesized catalysts. Excellent yield, short reaction time, simple workup procedure, and reusability of the catalyst are the prominent features of our synthetic route.

Automated summary

Vanadium substituted Molybdotungstophosphoric acid (H5PW6Mo4V2O40 center dot 14H(2)O) was found to be an effective solid catalyst for the one-pot synthesis of several quinoxaline derivatives from the condensation reaction between various substituted o-phenylenediamine and various aromatic benzil compounds in ethanol: water (1:1) solvent under reflux conditions. The synthetic route exhibited excellent yield, short reaction time, simple workup procedure, and reusability of the catalyst.