Journal
SYNTHESIS-STUTTGART
Volume 54, Issue 21, Pages 4834-4842Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1891-0797
Keywords
heteroarenes; indazole; C-H activation; C-H arylation; regioselectivity
Categories
Funding
- Euromed University of Fes
- CNRST of Rabat
- University of Nantes (CEISAM laboratorySymbiose group)
Ask authors/readers for more resources
A new solvent/ligand-controlled switchable C-H arylation of 1-methyl-4-nitro-1H-indazole catalyzed by Pd(OAc)(2) was achieved. Activation at the C7 position was promoted by a bidentate ligand in DMA, while arylation at the C3 position was directed by a phosphine ligand in H2O. The C3 and C7 arylation products were obtained in moderate to good yields and with high regioselectivity.
A new solvent/ligand-controlled switchable C-H arylation of 1-methyl-4-nitro-1H-indazole catalyzed by Pd(OAc)(2) was achieved. A bidentate ligand in DMA promoted the activation at C7 position, while a phosphine ligand in H2O oriented the arylation at C3 position. The C3 and C7 arylation products were obtained in moderate to good yields and with high regioselectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available