Synthesis of Nitrogen Heterocycles by a C-C Cross-Coupling/Cycloisomerization Strategy

Article Chemistry, Organic

Synthesis and Properties of Thieno[3,2-f]isoquinolines and Benzothieno[3,2-f]isoquinolines

Marian Blanco Ponce et al.

Summary: A variety of thieno[3,2-f]isoquinolines were synthesized by combining Pd catalysed cross-coupling reactions with Bronsted acid mediated cycloisomerisations, with high selectivity towards various functional groups. In addition, benzothieno[3,2-f]isoquinolines were prepared, representing a new heterocyclic core structure. The optical properties of selected compounds were studied, and solvatochromism characteristic of intramolecular charge transfer was observed for one compound with a push-pull structure.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2022)

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Article Chemistry, Organic

Palladium-Catalyzed Synthesis of Heterocyclic Ring Systems by Combination of Regioselective C-C with Twofold C-N Couplings

Peter Langer

Summary: The combination of regioselective palladium-catalyzed C-C with twofold C-N couplings allows for the synthesis of a variety of heterocyclic ring systems, including complex polyheterocyclic systems, which are of pharmacological relevance or interesting in the field of material science.

SYNLETT (2022)

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Article Chemistry, Organic

Cross-Coupling Reactions of Polyhalogenated Heterocycles

Peter Langer

SYNLETT (2022)

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Article Chemistry, Organic

Synthesis of Nitrogen Heterocycles by Domino C-N Coupling/Hydroamination Reactions

Peter Langer

Summary: The present article discusses the personalized Account on the synthesis of nitrogen heterocycles through domino C-N coupling/hydroamination reactions and related processes. The starting materials, 2-alkynyl-1-halohetarenes, are obtained regioselectively by Sonogashira reactions of various 1,2-dihalogenated heterocycles. The formation of more complex products is achieved through domino C-N coupling/hydroamination/C-H arylation reactions. These reactions result in the formation of new heterocyclic core structures with interesting pharmacological or fluorescence properties.

SYNLETT (2022)

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Article Chemistry, Organic