Iron-Catalyzed Synthesis of Pyrrolo[2,1-a]isoquinolines via 1,3-Dipolar Cycloaddition/Elimination/Aromatization Cascade and Modifications

We have developed an iron-catalyzed synthesis of pyrro-lo[2,1-a]isoquinoline derivatives with tetrahydroisoquinolines, arylacyl bromides, and nitroolefins. Highly functionalized pyrrolo[2,1-a]isoquinolines can be obtained in moderate to good yields through a three-component N-alkylationioxidative 1,3-dipolar cycloaddition/elimination/aromatization cascade. The obtained products in this study can be easily modified by easy chemical transformations to structurally complex molecules bearing privileged framework.

Automated summary

An iron-catalyzed synthesis of pyrro-lo[2,1-a]isoquinoline derivatives has been developed, achieving highly functionalized products through a three-component cascade reaction. The obtained products can be easily modified to form structurally complex molecules with privileged frameworks.