Perfusion Imaging and Clinical Outcome in Acute Minor Stroke With Large Vessel Occlusion

Article Clinical Neurology

Mismatch Profile Influences Outcome After Mechanical Thrombectomy

Jean-Marc Olivot et al.

Summary: This study found that baseline perfusion imaging profiles can predict the clinical response to mechanical thrombectomy, with TMM and MM profiles being associated with higher rates of functional recovery.

STROKE (2021)

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Article Clinical Neurology

Prediction of Early Neurological Deterioration in Individuals With Minor Stroke and Large Vessel Occlusion Intended for Intravenous Thrombolysis Alone

Pierre Seners et al.

Summary: The study aimed to develop and validate an easily applicable predictive score for early neurological deterioration following intravenous thrombolysis in patients with acute minor stroke and large vessel occlusion. The results showed that a score based on thrombus length and occlusion site had good discriminative power for identifying ENDi risk, with higher scores associated with greater probability of ENDi occurring.

JAMA NEUROLOGY (2021)

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Article Clinical Neurology

Intended Bridging Therapy or Intravenous Thrombolysis Alone in Minor Stroke With Basilar Artery Occlusion

Pierre Seners et al.

Summary: The study suggests that bridging therapy may be superior to IVT alone in minor stroke patients with basilar artery occlusion, leading to better outcomes without symptomatic intracranial hemorrhage.

STROKE (2021)

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Article Clinical Neurology

Perfusion and Diffusion Variables Predict Early Neurological Deterioration in Minor Stroke and Large Vessel Occlusion

Dong-Seok Gwak et al.

Summary: This study identified Tmax >6 seconds, Tmax >6 seconds - DWI, and Tmax 4-6 seconds as the optimal imaging variables for predicting early neurological deterioration in patients with mild stroke due to large vessel occlusion, independently associated with an increased risk of END.

JOURNAL OF STROKE (2021)

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Article Clinical Neurology

Perfusion Imaging and Clinical Outcome in Acute Ischemic Stroke with Large Core

Pierre Seners et al.

Summary: Mechanical thrombectomy (MT) may benefit acute stroke patients with large core when perfusion imaging shows a higher amount of penumbra. The study suggests that perfusion imaging can help identify which patients are suitable for MT based on the amount of salvageable tissue. Further randomized studies are needed to confirm these findings.

ANNALS OF NEUROLOGY (2021)

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Article Clinical Neurology

European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke

Eivind Berge et al.

Summary: Intravenous thrombolysis is the approved systemic reperfusion treatment for acute ischaemic stroke patients, with the ESO guidelines providing evidence-based recommendations. The guidelines highlight the importance of timely thrombolysis within 4.5 hours for improving functional outcomes, and recommend its use for specific patient subgroups such as those waking from sleep.

EUROPEAN STROKE JOURNAL (2021)

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Article Clinical Neurology