Journal
SMALL
Volume 18, Issue 35, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202203292
Keywords
antivirulence therapy; in situ vaccination; MRSA infection; nanotoxoid; photothermal; photodynamic therapy; pore-forming toxin; sphingomyelin liposome
Categories
Funding
- Outstanding Youth Fund Project of Zhejiang Natural Science Foundation [LR22H150001]
- Major Innovation Project of Wenzhou Science and Technology Bureau [2021ZY0002]
- Natural Science Foundation of China [81701828]
- Youth Fund Project of Zhejiang Natural Science Foundation [LQ22H180008]
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This study developed a smart targeted nanoformulation that can specifically deliver phototherapeutic agents to MRSA infection sites and effectively kill bacteria through near-infrared irradiation. Additionally, the nanoformulation can promote multiantigenic immunity to prevent secondary MRSA infections.
An effective therapeutic strategy against methicillin-resistant Staphylococcus aureus (MRSA) that does not promote further drug resistance is highly desirable. While phototherapies have demonstrated considerable promise, their application toward bacterial infections can be limited by negative off-target effects to healthy cells. Here, a smart targeted nanoformulation consisting of a liquid perfluorocarbon core stabilized by a lipid membrane coating is developed. Using vancomycin as a targeting agent, the platform is capable of specifically delivering an encapsulated photosensitizer along with oxygen to sites of MRSA infection, where high concentrations of pore-forming toxins trigger on-demand payload release. Upon subsequent near-infrared irradiation, local increases in temperature and reactive oxygen species effectively kill the bacteria. Additionally, the secreted toxins that are captured by the nanoformulation can be processed by resident immune cells to promote multiantigenic immunity that protects against secondary MRSA infections. Overall, the reported approach for the on-demand release of phototherapeutic agents into sites of infection could be applied against a wide range of high-priority pathogens.
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