4.6 Review

Peripheral biomarkers to diagnose obstructive sleep apnea in adults: A systematic review and meta-analysis

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Does ischemia-modified albumin level predict severity of obstructive sleep apnea?

Mustafa Duger et al.

Summary: The study found that levels of ischemia-modified albumin (IMA) were significantly elevated in patients with obstructive sleep apnea (OSA), and increased with disease severity. Serum IMA levels were found to be a more accurate predictor of OSA severity compared to other markers of inflammation.

SLEEP AND BREATHING (2021)

Article Cardiac & Cardiovascular Systems

Advances and challenges in pursuing biomarkers for obstructive sleep apnea: Implications for the cardiovascular risk ?

Adriana Lebkuchen et al.

Summary: The impact of obstructive sleep apnea (OSA) on cardiovascular function presents several challenges due to unclear mechanisms, prompting the need for the development of biomarkers to reveal potential risks.

TRENDS IN CARDIOVASCULAR MEDICINE (2021)

Review Clinical Neurology

MicroRNAs to guide medical decision-making in obstructive sleep apnea: A review

Lucia Pinilla et al.

Summary: Obstructive sleep apnea (OSA) is a common yet underdiagnosed sleep disorder associated with various diseases and leading causes of mortality. miRNAs have the potential to be new indicators for managing pediatric and adult OSA, offering translational applicability, particularly in diagnosis and therapy allocation.

SLEEP MEDICINE REVIEWS (2021)

Article Clinical Neurology

Metrics of sleep apnea severity: beyond the apnea-hypopnea index

Atul Malhotra et al.

Summary: Obstructive sleep apnea (OSA) affects nearly 1 billion people globally with established cardiovascular and neurocognitive consequences. The apnea-hypopnea index (AHI) is a widely studied metric of OSA severity, but alternative metrics like hypoxic burden and arousal intensity are being explored. Future research should focus on capturing clinically meaningful OSA endophenotypes using genetics, blood biomarkers, machine learning, and wearable technologies.

SLEEP (2021)

Review Clinical Neurology

A systematic review of COVID-19 and obstructive sleep apnoea

Michelle A. Miller et al.

Summary: This study reviewed the relationship between OSA and COVID-19 outcomes, finding that risk factors associated with OSA are also linked to poor COVID-19 outcomes. Plausible mechanisms suggest OSA may independently increase the risk of death from COVID-19. The study also highlights the major impact of COVID-19 on the diagnosis and treatment of OSA.

SLEEP MEDICINE REVIEWS (2021)

Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Review Clinical Neurology

Epigenetics of obstructive sleep apnea syndrome: a systematic review

Brittany A. Leader et al.

Summary: Obstructive sleep apnea (OSA) is a chronic disease associated with multiple health disorders, and current diagnostic strategies are limited. Epigenetic signatures could play a significant role in developing diagnostic and therapeutic tools for OSA. Studies have found unique epigenetic changes in OSA patients compared to healthy controls, mainly related to metabolic and inflammatory pathways.

JOURNAL OF CLINICAL SLEEP MEDICINE (2021)

Review Medicine, General & Internal

Circadian Biology in Obstructive Sleep Apnea

Bala S. C. Koritala et al.

Summary: Obstructive sleep apnea can disrupt the molecular clock and impact various biological rhythms, potentially worsening cardiovascular or cognitive outcomes. Understanding circadian biology in the context of OSA could be crucial for improving diagnosis and treatment methods.

DIAGNOSTICS (2021)

Review Critical Care Medicine

Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine

Andrey Zinchuk et al.

CHEST (2020)

Article Clinical Neurology

Night-to-night fluctuations in sleep apnea severity: diagnostic and treatment implications

Joseph M. Dzierzewski et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2020)

Editorial Material Clinical Neurology

Greater health care utilization and cost associated with untreated sleep apnea COMMENT

Qinglan Ding et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2020)

Article Respiratory System

Is Vimentin the Cause or Effect of Obstructive Sleep Apnea Development?

Bugra Kerget et al.

Review Medicine, General & Internal

Diagnosis and Management of Obstructive Sleep Apnea A Review

Daniel J. Gottlieb et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Clinical Neurology

Proteomic biomarkers of sleep apnea

Aditya Ambati et al.

SLEEP (2020)

Review Clinical Neurology

On the rise and fall of the apnea-hypopnea index: A historical review and critical appraisal

Dirk A. Pevernagie et al.

JOURNAL OF SLEEP RESEARCH (2020)

Review Respiratory System

Endotypes and phenotypes in obstructive sleep apnea

Atul Malhotra et al.

CURRENT OPINION IN PULMONARY MEDICINE (2020)

Review Otorhinolaryngology

A review of the OMICS for management of patients with obstructive sleep apnoea

Luana Conte et al.

ACTA OTORHINOLARYNGOLOGICA ITALICA (2020)

Review Respiratory System

Obstructive sleep apnea and comorbidities: a dangerous liaison

Maria R. Bonsignore et al.

MULTIDISCIPLINARY RESPIRATORY MEDICINE (2019)

Article Critical Care Medicine

Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis

Adam V. Benjafield et al.

LANCET RESPIRATORY MEDICINE (2019)

Article Critical Care Medicine

The Last 25 Years of Obstructive Sleep Apnea Epidemiology-and the Next 25?

Paul E. Peppard et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Medicine, Research & Experimental

Metabolic Profile in Patients with Mild Obstructive Sleep Apnea

Luciana Oliveira e Silva et al.

METABOLIC SYNDROME AND RELATED DISORDERS (2018)

Editorial Material Critical Care Medicine

Challenges in obstructive sleep apnoea

Walter T. McNicholas et al.

LANCET RESPIRATORY MEDICINE (2018)

Article Physiology

8-isoprostanes and resistin as markers of vascular damage in non-hypersomnolent obstructive sleep apnoea patients

Radostina Vlaeva Cherneva et al.

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING (2017)

Review Biochemistry & Molecular Biology

Obstructive Sleep Apnea and Hallmarks of Aging

Laetitia S. Gaspar et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Article Medicine, Research & Experimental

Making Meaningful Clinical Use of Biomarkers

Matthew J. Selleck et al.

BIOMARKER INSIGHTS (2017)

Editorial Material Clinical Neurology

Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health

Janet M. Mullington et al.

SLEEP (2016)

Editorial Material Clinical Neurology

Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health

Janet M. Mullington et al.

SLEEP (2016)

Article Respiratory System

Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome

Kostas Archontogeorgis et al.

PULMONARY MEDICINE (2016)

Article Clinical Neurology

Diagnostic Capability of Biological Markers in Assessment of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Graziela De Luca Canto et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2015)

Article Dentistry, Oral Surgery & Medicine

Can we use serum copeptin levels as a biomarker in obstructive sleep apnea syndrome?

Omer Tank Selcuk et al.

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY (2015)

Review Primary Health Care

Home Sleep Tests for Obstructive Sleep Apnea (OSA)

Mukesh Kapoor et al.

JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE (2015)

Review Clinical Neurology

Biomarkers associated with obstructive sleep apnea: A scoping review

Graziela De Luca Canto et al.

SLEEP MEDICINE REVIEWS (2015)

Article Public, Environmental & Occupational Health

Increased Prevalence of Sleep-Disordered Breathing in Adults

Paul E. Peppard et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2013)

Article Anesthesiology

Proportion of surgical patients with undiagnosed obstructive sleep apnoea

M. Singh et al.

BRITISH JOURNAL OF ANAESTHESIA (2013)

Article Biochemistry & Molecular Biology

Gene expression profiles in peripheral blood mononuclear cells of asian obstructive sleep apnea patients

Ning-Hung Chen et al.

Biomedical Journal (2013)

Article Anesthesiology

Meta-analysis of the association between obstructive sleep apnoea and postoperative outcome

R. Kaw et al.

BRITISH JOURNAL OF ANAESTHESIA (2012)

Article Clinical Neurology

Home set-up polysomnography in the assessment of suspected obstructive sleep apnea

Angela J. Campbell et al.

JOURNAL OF SLEEP RESEARCH (2011)

Article Medicine, Research & Experimental

Laboratory versus portable sleep studies: A meta-analysis

Mark D. Ghegan et al.

LARYNGOSCOPE (2006)