The correlation between the body shape and otolithic function in patients with obstructive sleep apnea

Objective: To identify the typical pattern of changes of vestibular-evoked myogenic potentials (VEMPs) and explore the relationship between VEMPs and the anthropometry factors in patients with obstructive sleep apnea (OSA).Methods: Patients diagnosed as OSA after overnight polysomnography (PSG) tests were enrolled as the study group. Healthy volunteers were recruited as the control group. Anthropometry data of the body shape and VEMPs results were collected completely. The correlation analysis was conducted among those parameters.Results: Forty-nine patients with OSA who were diagnosed in the Therapy Center of Sleep-disordered Breathing in our hospital and sex-and age-matched healthy controls as well. Significant changes in ocular and cervical VEMPs (oVEMP and cVEMP) in the study group were observed, which were reduced response rates, elevated thresholds, decreased amplitudes, and prolonged first wave latencies. In oVEMP, the first wave (n1) latency was significantly correlated with weight, body mass index (BMI), neck circumference, waist circumference, hip circumference, and apnea hypopnea index (AHI). In a tentative application, combined use of BMI and oVEMP n1 latency increased the detection rate during OSA screening prior to PSG.Conclusion: OSA can negatively affect function of otolithic organs and their pathways. The first wave latency of the VEMPs waveform may be another important parameter to define peripheral nervous system lesions caused by systemic diseases as OSA.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

This study aimed to identify the typical pattern of changes in vestibular-evoked myogenic potentials (VEMPs) and explore the relationship between VEMPs and anthropometry factors in patients with obstructive sleep apnea (OSA). The results showed significant changes in ocular and cervical VEMPs in the OSA patients, including reduced response rates, elevated thresholds, decreased amplitudes, and prolonged first wave latencies. The first wave latency of the VEMPs waveform may serve as an important parameter for defining peripheral nervous system lesions caused by OSA.