Severity and mortality of COVID-19 in patients with systemic sclerosis: a Brazilian multicenter study

Summary: The study found that COVID-19 patients with systemic autoimmune rheumatic diseases may have a higher risk of hospitalization, ICU admission, acute renal failure, and venous thromboembolism compared to those without systemic ARDs. These risks may be largely influenced by comorbidities, except for the risk of venous thromboembolism.

ARTHRITIS & RHEUMATOLOGY (2021)

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Article Rheumatology

Outcomes of COVID-19 in patients with rheumatoid arthritis: A multicenter research network study in the United States

Rahul Raiker et al.

Summary: The study found that before matching, RA patients had higher risks compared to non-RA patients in COVID-19 outcomes, but after matching, most outcomes showed no significant difference, implying the risk may be attributed to adjusted factors. However, after matching, the risks of VTE and sepsis were still higher in the RA cohort, indicating RA as an independent risk factor.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2021)

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Article Rheumatology

Hematopoietic stem cell transplantation for systemic sclerosis: Brazilian experience

Alvaro Henrique-Neto et al.

Summary: This study investigated the clinical outcomes of 70 SSc patients who underwent autologous hematopoietic progenitor cell transplantation. The results showed that HSCT can improve skin and interstitial lung involvement, increasing patients' overall survival and progression-free survival rates.

ADVANCES IN RHEUMATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

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Review Rheumatology

A comprehensive framework for navigating patient care in systemic sclerosis: A global response to the need for improving the practice of diagnostic and preventive strategies in SSc

Lesley Ann Saketkoo et al.

Summary: Systemic sclerosis (SSc) is the most lethal rheumatologic condition, often leading to death from complications like pulmonary fibrosis and pulmonary hypertension. Early detection and treatment are crucial in preventing irreversible organ damage.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2021)

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Article Pharmacology & Pharmacy

Covid-19 and Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments

Clodoveo Ferri et al.

Summary: The prevalence of symptomatic Covid-19 was significantly higher in ASD patients in Italy compared to the general population, with variations in different regions and subgroups. Patients undergoing specific treatments or with specific clinical features showed lower prevalence rates. This suggests the importance of developing targeted prevention/management strategies during the current pandemic.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Biochemistry & Molecular Biology

Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial

Ana C. Medeiros-Ribeiro et al.

Summary: In a large prospective phase 4 trial, vaccination with CoronaVac, an inactivated SARS-CoV-2 vaccine, elicited significantly lower virus-specific IgG antibodies and neutralizing antibodies in patients with autoimmune rheumatic diseases than in age- and sex-matched healthy control trial participants.

NATURE MEDICINE (2021)

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Review Allergy

SARS-CoV-2 Vaccines: Where Are We Now?

Katie L. Flanagan et al.

Summary: The best and safest way to control the COVID-19 pandemic is through widespread vaccination. Currently, there are 289 vaccines in development, with 20 publicly available and over 3.3 billion doses administered globally. Despite progress, challenges remain in vaccinating the world population in a timely manner and addressing unanswered questions about immunity and emerging variants.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Rheumatology

Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases

Victoria Furer et al.

Summary: This paper reviews the current data on COVID-19 infection in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and discusses the efficacy and safety of vaccination against COVID-19 in this population. It proposes preliminary considerations for vaccination based on expert opinion and knowledge of vaccination in AIIRD patients.

RMD OPEN (2021)

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Article Rheumatology

Impact of Covid-19 on clinical care and lived experience of systemic sclerosis: An international survey from EURORDIS-Rare Diseases Europe

Michael Hughes et al.

Summary: The impact of Covid-19 on systemic sclerosis patients has been significant, affecting both clinical care and emotional well-being. Changes in clinical care delivery, such as telemedicine consultations, have been well received by patients during this period.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2021)

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Article Rheumatology