4.6 Article

Effect of Intranasal Oxytocin on Resting-state Effective Connectivity in Schizophrenia

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Summary: A systematic review and meta-analysis on the effects of intranasal oxytocin for treating negative symptoms in schizophrenia showed inconsistent results, with no consistent beneficial effect found. Higher doses of oxytocin may have a beneficial effect on negative symptoms, but further studies are needed to confirm this. There was no beneficial effect of oxytocin on positive symptoms in the main meta-analysis, although a potential advantage of higher doses was suggested in the dose-response meta-analysis.

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