Voltammetric Determination of Acetaminophen with Ag/PANI/PW12 Nanocomposites-Modified Carbon Paste Electrodes

In this research, Ag polyaniline heteropoly acid (Ag/PANI/PW12) nanocomposites and modified electrodes were used to modify carbon paste electrode (CPE) voltammetric determination of paracetamol, respectively. Differential pulse voltammetry was investigated in potassium chloride (KCl) electrolyte at the modified electrode surface and successfully applied to paracetamol in a potential range of 0.5-1 V under different pH conditions. However, the best result was obtained at pH 2.0. The results also revealed that the modified electrode shows an electrocatalytic activity towards the paracetamol oxidation under the optimum conditions. The anodic peak current showed a linear relationship with paracetamol concentrations in a range of 6.62 x 10(-8)-9.29 x 10(-5) M, with a regression equation of Y = 2 x 10(-5)X - 1 x 10(-6) (R-2 = 0.9999) and a limit of detection of 0.016 mu M (signal-to-noise ratio = 3). The cyclic voltammetric results showed a well-defined oxidation peak with good reproducibility for the modified electrode (RSD = 2.6, n = 10). This technique was applied to the demonstration of paracetamol in wastewater and paracetamol tablet samples.

Automated summary

In this study, Ag/PANI/PW12 nanocomposites and modified electrodes were used to modify carbon paste electrode (CPE) for the voltammetric determination of paracetamol. The modified electrode showed electrocatalytic activity towards paracetamol oxidation under the optimum conditions, with good reproducibility and a low limit of detection.