Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 25, Issue 9, Pages 1367-1373Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201402980
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Funding
- EPSRC
- Ondine Biopharma
- Alan Howard Scholarship
- Energy Futures Lab, Imperial College London
- EPSRC [EP/K035274/1, EP/H046380/1, EP/K039946/1, EP/K03930X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [955465, EP/H046380/1, EP/K03930X/1, EP/K035274/1, EP/C544838/1, EP/K039946/1] Funding Source: researchfish
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The prevalence of healthcare-associated infection caused by multidrug-resistant bacteria is of critical concern worldwide. It is reported on the development of a bactericidal surface prepared by use of a simple, upscalable, two-step dipping strategy to incorporate crystal violet and di(octyl)-phosphinic-acid-capped zinc oxide nanoparticles into medical grade silicone, as a strategy to reduce the risk of infection. The material is characterized by UV-vis absorbance spectroscopy, X-ray photoelectron spectroscopy (XPS), inductively coupled plasma-optical emission spectroscopy (ICP-OES) and transmission electron microscopy (TEM) and confirmed the incorporation of the ZnO nanoparticles in the polymer. The novel system proves to be a highly versatile bactericidal material when tested against both Staphylococcus aureus and Escherichia coli, key causative micro-organisms for hospitalacquired infection (HAI). Potent antimicrobial activity is noted under dark conditions, with a significant enhancement exhibits when the surfaces are illuminated with a standard hospital light source. This polymer has the potential to decrease the risk of HAI, by killing bacteria in contact with the surface.
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