Nonspecific ventricular repolarization abnormalities: A wolf in sheep's clothing

The term nonspecific ventricular repolarization abnormalities refers to a set of minor alterations of the ST segment and/or the T wave. For a long time, they have been of little clinical interest as they do not translate into specific diagnoses. It has even been asserted that they constitute benign electrocardiographic findings. Their presence has been reported in various cardiovascular and non-cardiovascular diseases. However, it is frequently identified in apparently healthy asymptomatic people. A growing number of studies demonstrate their importance as predictors of cardiovascular morbidity and mortality, expanding their spectrum towards cardiovascular prevention. In light of the body of scientific evidence, it is imperative that the traditional view of nonspecific ventricular repolarization abnormalities changes.(c) 2022 Elsevier Espana, S.L.U. and Sociedad Espanola de Medicina Interna (SEMI). All rights reserved.

Automated summary

Nonspecific ventricular repolarization abnormalities refer to minor changes in the ST segment and/or the T wave on an electrocardiogram. They have been considered insignificant and benign findings for a long time. However, increasing evidence suggests that they can serve as predictors of cardiovascular morbidity and mortality, challenging the traditional view.