Chronic obstructive pulmonary disease (COPD) mortality trends worldwide: An update to 2019

Article Critical Care Medicine

Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment

Ian A. Yang et al.

Summary: Chronic obstructive pulmonary disease (COPD) is not only caused by smoking, but also related to non-smoking factors such as air pollution and occupational exposure. COPD in never-smokers has milder symptoms but frequent exacerbations.

LANCET RESPIRATORY MEDICINE (2022)

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Editorial Material Critical Care Medicine

GETting to know the many causes and faces of COPD

Hyun Lee et al.

LANCET RESPIRATORY MEDICINE (2022)

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Review Critical Care Medicine

Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis

Davies Adeloye et al.

Summary: This study aimed to estimate the prevalence and risk factors of chronic obstructive pulmonary disease (COPD) globally, regionally, and nationally, in order to guide policy and population interventions.

LANCET RESPIRATORY MEDICINE (2022)

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Article Critical Care Medicine

Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder

Michael H. Cho et al.

Summary: Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease. Genetic variations play a significant role in COPD risk and heterogeneity, with hundreds of genetic variants identified. Further research with larger studies, more ancestral diversity, and improved profiling methods is needed. Integrating genetic data with other omics data and comprehensive COPD phenotypes, as well as understanding the causal mechanisms of genetic risk variants, can inform novel approaches to COPD pathobiology and treatment strategies.

LANCET RESPIRATORY MEDICINE (2022)

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Review Economics

Cost analysis of chronic obstructive pulmonary disease (COPD): a systematic review

Celia Gutierrez Villegas et al.

Summary: This systematic review analyzed 18 publications on COPD costs from 2015 to 2020, finding that direct healthcare costs and indirect costs were the most studied. Studies showed that healthcare expenses for COPD patients in European countries increased with disease severity and frequency of exacerbations, while loss of productivity and premature retirement were highlighted as main sources of indirect costs.

HEALTH ECONOMICS REVIEW (2021)

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Article Public, Environmental & Occupational Health

Who Smokes in Europe? Data From 12 European Countries in the TackSHS Survey (2017-2018)

Silvano Gallus et al.

Summary: A survey conducted in 12 European countries found an overall smoking prevalence of 25.9%, with 31.0% in men and 21.2% in women. Smoking prevalence decreased with age, level of education, and self-rated household economic level. Lower socio-economic status was identified as a major determinant of smoking habit in both sexes.

JOURNAL OF EPIDEMIOLOGY (2021)

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Article Environmental Sciences

Global burden of COPD attributable to ambient PM2.5 in 204 countries and territories, 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019

Xiaorong Yang et al.

Summary: The study found that the global burden of COPD attributable to ambient PM2.5 significantly increased from 1990 to 2019, but the death rate and disability-adjusted life years rate slightly decreased. Most burden occurred in middle sociodemographic index regions, but the fastest growth was in low SDI regions. East Asia and South Asia were identified as high-risk areas for COPD deaths and DALYs attributable to PM2.5, with China and India carrying the heaviest burden.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Medicine, General & Internal

Four Decades of COPD Mortality Trends: Analysis of Trends and Multiple Causes of Death

Alberto Fernandez-Garcia et al.

Summary: This study analyzed COPD mortality trends in Galicia from 1980 to 2017, finding a steady decrease in mortality rates since 1996 and an increase in the age of death. Taking into account deaths where COPD was not the underlying cause led to a 42% increase in the mortality burden.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Respiratory System