Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 301, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.resp.2022.103884
Keywords
Airway smooth muscle; Remodeling; Asthma; Bronchoscopy; Imaging; Polarization-sensitive optical coherence tomography
Categories
Funding
- National Australian Health and Medical Research Council (NHMRC) [APP1180854]
- Australian Research Council [CE140100003]
- University of Western Australia (UWA) University Postgraduate Award (UPA)
- SIRF scholarship
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This paper investigates the feasibility of quantifying airway wall thickness using PS-OCT technology in vivo, and analyzes the constraints that airway size poses to imaging techniques as well as the impact of physiological processes on measurements through the application of a mathematical model and human biobank data.
Clinical visualization and quantification of the amount and distribution of airway smooth muscle (ASM) in the lungs of individuals with asthma has major implications for our understanding of airway wall remodeling as well as treatments targeted at the ASM. This paper theoretically investigates the feasibility of quantifying airway wall thickness (focusing on the ASM) throughout the lung in vivo by means of bronchoscopic polarization-sensitive optical coherence tomography (PS-OCT). Using extensive human biobank data from subjects with and without asthma in conjunction with a mathematical model of airway compliance, we define constraints that airways of various sizes pose to any endoscopic imaging technique and how this is impacted by physiologically relevant processes such as constriction, inflation and deflation. We identify critical PS-OCT system parameters and pinpoint parts of the airway tree that are conducive to successful quantification of ASM. We further quantify the impact of breathing and ASM contraction on the measurement error and recommend strategies for standardization and normalization
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