Journal
RESEARCH IN VETERINARY SCIENCE
Volume 145, Issue -, Pages 54-62Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2022.02.010
Keywords
Dendritic cell; Cytokines; Innate immunity; Lymphocyte polarization
Categories
Funding
- Ministry of Agriculture of Czech Republic [RO0518, QJ1510218]
- Ministry of Education, Youth and Sport of Czech Republic [EF16_025/0007397]
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This study investigated the effects of different cytokine microenvironments on porcine dendritic cells and found that an IFNγ-rich microenvironment induced a higher inflammatory response and release of polarizing cytokines. Different cytokine microenvironments have the potential to modulate the activation ability of dendritic cells.
Dendritic cells (DCs) represent a heterogeneous group of major antigen-presenting cells, responding to different stimuli in their microenvironment. They are able to activate naive T-cells and drive their polarization towards effector types. However, the effect of different Th-polarizing cytokine microenvironment on porcine DCs remains poorly described. Therefore, the effect of IFN gamma or IL4 rich microenvimnment on porcine monocyte-derived dendritic cells and their activation, antigen recognition and cytokine secretion towards T-cell polarization were studied in vitro. IFN gamma-rich microenvimnment induced a higher proinflammatory response and release of Th1/Th17-polarizing cytokines (IL1 beta, IL12p35, IL23p19), while anti-inflammatory properties (IL10, TGF beta) was not affected by a cytokine micmenvironment. From the achieved results, we propose that different cytokine microenvimnment has the potential to modulate dendritic cells and their ability to activate T-cells.
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