Biochemical and molecular mechanisms of antibiotic resistance in Salmonella spp.

Salmonella is a diverse Gram-negative bacterium that represents the major disease burden worldwide. According to WHO, Salmonella is one of the fourth global causes of diarrhoeal disease. Antibiotic resis-tance is a worldwide health concern, and Salmonella spp. is one of the microorganisms that can evade the toxicity of antimicrobials via antibiotic resistance. This review aims to deliver in-depth knowledge of the molecular mechanisms and the underlying biochemical alterations perceived in antibiotic resistance in Salmonella. This information will help understand and mitigate the impact of antibiotic-resistant bacteria on humans and contribute to the state-of-the-art research developing newer and more potent antibiotics.(c) 2022 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Automated summary

Salmonella is a diverse Gram-negative bacterium and one of the major global causes of diarrheal disease. Antibiotic resistance is a worldwide concern, and Salmonella can evade the toxicity of antimicrobials through this mechanism. This review aims to provide in-depth understanding of the molecular mechanisms and biochemical alterations underlying antibiotic resistance in Salmonella, which can contribute to the development of newer and more potent antibiotics.