4.6 Review

Myostatin: a multifunctional role in human female reproduction and fertility - a short review

Related references

Note: Only part of the references are listed.
Article Agriculture, Dairy & Animal Science

Reproduction traits of heterozygous myostatin knockout sows crossbred with homozygous myostatin knockout boars

Sheng-zhong Han et al.

Summary: Heterozygous MSTN+/- sows exhibit delayed pubertal age, increased number of services per pregnancy, and lower litter size compared to wild type sows. Offsprings derived from mating heterozygous MSTN+/- sows with homozygous MSTN-/- boars show a lower proportion of homozygous MSTN-/- piglets, with reports of health issues in some homozygous MSTN-/- piglets.

REPRODUCTION IN DOMESTIC ANIMALS (2021)

Article Medicine, Research & Experimental

Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via upregulating SERPINE1 expression in patients with PCOS

Long Bai et al.

Summary: Clinical investigations have shown that GDF8 expression is elevated in PCOS patients, affecting glucose metabolism in hGL cells possibly through mediation by SERPINE1, with TP53 playing a crucial role in the stimulated increase of SERPINE1. These findings suggest a potential role for GDF8 in metabolic disorders in PCOS.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Endocrinology & Metabolism

The Exploration of Poor Ovarian Response-Related Risk Factors: A Potential Role of Growth Differentiation Factor 8 in Predicting Ovarian Response in IVF-ET Patient

Long Bai et al.

Summary: This study found that multiple factors are closely related to poor ovarian response (POR), including aging, obesity, endometriosis, surgery history, and IVF treatment, while irregular menstrual cycles and PCOS contribute to hyperovarian response (HOR). Additionally, POR patients exhibited a decrease in numbers of MII oocytes and available embryos, thereby manifesting a lower clinical pregnancy rate. Levels of GDF-8, ALK5, and ACVR2B were higher in POR patients compared to control groups, while the expression level of ACVR2A decreased in poor ovarian response patients.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Cell Biology

Upregulation of Low-Density Lipoprotein Receptor of the Steroidogenesis Pathway in the Cumulus Cells Is Associated with the Maturation of Oocytes and Achievement of Pregnancy

Myung Joo Kim et al.

Summary: The maturation of oocytes is influenced by cumulus cells and plays a role in pregnancy rates, with potential factors in cumulus cells being identified to aid in successful pregnancies through assisted reproductive techniques. By analyzing mRNA expression differences between young and old cumulus cells, as well as in pregnancy and non-pregnancy groups, specific genes involved in ovarian steroidogenesis regulation were revealed. It was found that upregulation of the low-density lipoprotein receptor in cumulus cells was associated with higher maturity rates of oocytes and increased pregnancy rates in infertile women undergoing IVF procedures.

CELLS (2021)

Article Biochemistry & Molecular Biology

High ovarian GDF-8 levels contribute to elevated estradiol production in ovarian hyperstimulation syndrome by stimulating aromatase expression

Lanlan Fang et al.

Summary: The study demonstrates that GDF-8 stimulates aromatase expression and estrogen production in the ovaries through the TGF-beta signaling pathway. The roles of the GDF-8 system in the pathogenesis of OHSS are confirmed in rat models and clinical samples.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Comparative analysis of single-cell parallel sequencing approaches in oocyte application

Yan Qian et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

Review Endocrinology & Metabolism

Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls

Selma Feldman Witchel et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2019)

Article Cardiac & Cardiovascular Systems

Absence of Myostatin Improves Cardiac Function Following Myocardial Infarction

Sarina Lim et al.

HEART LUNG AND CIRCULATION (2018)

Review Chemistry, Medicinal

Inhibitors of cytochrome P450 (CYP) 1B1

Raphael Dutour et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Cell Biology

TGF-β Family Signaling in Connective Tissue and Skeletal Diseases

Elena Gallo MacFarlane et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Article Cell Biology

TGF-β Family Signaling in Tumor Suppression and Cancer Progression

Joan Seoane et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Article Obstetrics & Gynecology

Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells

Hsun-Ming Chang et al.

FERTILITY AND STERILITY (2016)

Article Medicine, General & Internal

Polycystic Ovary Syndrome

Christopher R. McCartney et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Obstetrics & Gynecology

15 Follistatin-Like 3 Protein (FSTL3) is upregulated in preeclampsia

Rita Horvath et al.

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health (2016)

Article Obstetrics & Gynecology

Association of in vitro fertilization outcome with circulating insulin-like growth factor components prior to cycle initiation

Ilana Ramer et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

Article Biochemistry & Molecular Biology

Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy

Estibaliz Castillero et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Obstetrics & Gynecology

Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis

Patrizia Carrarelli et al.

FERTILITY AND STERILITY (2015)

Article Endocrinology & Metabolism

Recombinant BMP4 and BMP7 Increase Activin A Production by Up-Regulating Inhibin βA Subunit and Furin Expression in Human Granulosa-Lutein Cells

Hsun-Ming Chang et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Cell Biology

Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells

Hsun-Ming Chang et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)

Review Endocrinology & Metabolism

Role of the extracellular and intracellular loops of follicle-stimulating hormone receptor in its function

Antara A. Banerjee et al.

FRONTIERS IN ENDOCRINOLOGY (2015)

Article Obstetrics & Gynecology

Follistatin-Like 3 Across Gestation in Preeclampsia and Uncomplicated Pregnancies Among Lean and Obese Women

Sandra A. Founds et al.

REPRODUCTIVE SCIENCES (2015)

Article Cardiac & Cardiovascular Systems

Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure

Nadine Biesemann et al.

CIRCULATION RESEARCH (2014)

Review Obstetrics & Gynecology

The physiology and clinical utility of anti-Mllerian hormone in women

Didier Dewailly et al.

HUMAN REPRODUCTION UPDATE (2014)

Review Obstetrics & Gynecology

Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis

Annemieke Kasius et al.

HUMAN REPRODUCTION UPDATE (2014)

Article Endocrinology & Metabolism

Myostatin Is Localized in Extravillous Trophoblast and Up-Regulates Migration

Hassendrini N. Peiris et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Endocrinology & Metabolism

Role of Activin-A and Myostatin and Their Signaling Pathway in Human Myometrial and Leiomyoma Cell Function

Md Soriful Islam et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Review Biochemistry & Molecular Biology

The regulation of muscle protein turnover in diabetes

Biruh Workeneh et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Muscle wasting in heart failure: An overview

Stephan von Haehling et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential

H. Q. Han et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Article Endocrinology & Metabolism

Antimullerian Hormone Levels Are Strongly Associated With Live-Birth Rates After Assisted Reproduction

Thomas Brodin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Oncology

Changes in Myostatin Signaling in Non-Weight-Losing Cancer Patients

Zaira Aversa et al.

ANNALS OF SURGICAL ONCOLOGY (2012)

Article Medical Laboratory Technology

Decreased maternal and placental concentrations of follistatin-like 3 in gestational diabetes

Dongxiao Hu et al.

CLINICA CHIMICA ACTA (2012)

Article Biochemistry & Molecular Biology

Cell-type specific regulation of myostatin signaling

Dwi U. Kemaladewi et al.

FASEB JOURNAL (2012)

Article Obstetrics & Gynecology

Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women

Kannamannadiar Jayaprakasan et al.

FERTILITY AND STERILITY (2012)

Review Obstetrics & Gynecology

Ovarian antral folliculogenesis during the human menstrual cycle: a review

Angela R. Baerwald et al.

HUMAN REPRODUCTION UPDATE (2012)

Article Obstetrics & Gynecology

Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia

Jing Guo et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2012)

Article Developmental Biology

The expression and potential functions of placental myostatin

H. N. Peiris et al.

PLACENTA (2012)

Article Biotechnology & Applied Microbiology

Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

A. Regassa et al.

BMC GENOMICS (2011)

Editorial Material Cardiac & Cardiovascular Systems

Increased plasma myostatin in heart failure

Damien Gruson et al.

EUROPEAN JOURNAL OF HEART FAILURE (2011)

Article Obstetrics & Gynecology

Altered expression of activin, cripto, and follistatin in the endometrium of women with endometrioma

Ana Luiza L. Rocha et al.

FERTILITY AND STERILITY (2011)

Article Obstetrics & Gynecology

Human cumulus cell gene expression as a biomarker of pregnancy outcome after single embryo transfer

Kathryn Michelle Gebhardt et al.

FERTILITY AND STERILITY (2011)

Article Biochemistry & Molecular Biology

Cytokines: Signalling molecules controlling ovarian functions

Alexander V. Sirotkin

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)

Article Endocrinology & Metabolism

Activin-A and Myostatin Response and Steroid Regulation in Human Myometrium: Disruption of Their Signalling in Uterine Fibroid

Pasquapina Ciarmela et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Article Endocrinology & Metabolism

Connective Tissue Growth Factor Is Required for Normal Follicle Development and Ovulation

Takashi Nagashima et al.

MOLECULAR ENDOCRINOLOGY (2011)

Article Multidisciplinary Sciences

Myostatin Is Elevated in Congenital Heart Disease and After Mechanical Unloading

Lawrence T. Bish et al.

PLOS ONE (2011)

Article Endocrinology & Metabolism

Placental expression of myostatin and follistatin-like-3 protein in a model of developmental programming

Hassendrini N. Peiris et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

Article Cardiac & Cardiovascular Systems

Genetic Deletion of Myostatin From the Heart Prevents Skeletal Muscle Atrophy in Heart Failure

Joerg Heineke et al.

CIRCULATION (2010)

Article Cardiac & Cardiovascular Systems

Myostatin activation in patients with advanced heart failure and after mechanical unloading

Isaac George et al.

EUROPEAN JOURNAL OF HEART FAILURE (2010)

Article Biochemistry & Molecular Biology

Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells

Yuewen Chen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Article Sport Sciences

Myostatin Decreases with Aerobic Exercise and Associates with Insulin Resistance

Dustin S. Hittel et al.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2010)

Article Reproductive Biology

Mural granulosa cell gene expression associated with oocyte developmental competence

Jin-Yi Jiang et al.

JOURNAL OF OVARIAN RESEARCH (2010)

Article Cell Biology

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

Anne Ulrike Trendelenburg et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)

Article Endocrinology & Metabolism

Presence, Actions, and Regulation of Myostatin in Rat Uterus and Myometrial Cells

Pasquapina Ciarmela et al.

ENDOCRINOLOGY (2009)

Article Obstetrics & Gynecology

High serum follistatin levels in women with ovarian endometriosis

P. Florio et al.

HUMAN REPRODUCTION (2009)

Article Physiology

Effects of spaceflight on murine skeletal muscle gene expression

David L. Allen et al.

JOURNAL OF APPLIED PHYSIOLOGY (2009)

Article Neurosciences

Myostatin represses physiological hypertrophy of the heart and excitation-contraction coupling

Buel D. Rodgers et al.

JOURNAL OF PHYSIOLOGY-LONDON (2009)

Article Endocrinology & Metabolism

Growth-differentiation factor-8 (GDF-8) in the uterus: its identification and functional significance in the golden hamster

Chun Lung Wong et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2009)

Article Cell & Tissue Engineering

BMP-11 and Myostatin Support Undifferentiated Growth of Human Embryonic Stem Cells in Feeder-Free Cultures

Nicholas R. F. Hannan et al.

CLONING AND STEM CELLS (2009)

Review Obstetrics & Gynecology

Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome

Sergio Reis Soares et al.

HUMAN REPRODUCTION UPDATE (2008)

Review Obstetrics & Gynecology

Follicle dynamics and anovulation in polycystic ovary syndrome

Stephen Franks et al.

HUMAN REPRODUCTION UPDATE (2008)

Review Biochemistry & Molecular Biology

Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development

Michael K. Skinner et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2008)

Review Medicine, Research & Experimental

Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations

Gerald J. Prud'homme

LABORATORY INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Ubiquitous expression of myostatin in chicken embryonic tissues: Its high expression in testis and ovary

Kaiyu Kubota et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2007)

Article Endocrinology & Metabolism

Myostatin regulates glucose uptake in BeWo cells

Nisha Antony et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

Article Cell Biology

Oocytes determine cumulus cell lineage in mouse ovarian follicles

Francisco J. Diaz et al.

JOURNAL OF CELL SCIENCE (2007)

Article Multidisciplinary Sciences

Lack of myostatin results in excessive muscle growth but impaired force generation

Helge Amthor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Clinical Neurology

Myostatin does not regulate cardiac hypertrophy or fibrosis

Ronald D. Cohn et al.

NEUROMUSCULAR DISORDERS (2007)

Article Urology & Nephrology

Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia

D. F. Sun et al.

KIDNEY INTERNATIONAL (2006)

Review Developmental Biology

TGF-β superfamily members and ovarian follicle development

Phil G. Knight et al.

REPRODUCTION (2006)

Article Agriculture, Dairy & Animal Science

Role of serum myostatin during the lactation period

Tohru Hosoyama et al.

JOURNAL OF REPRODUCTION AND DEVELOPMENT (2006)

Article Cardiac & Cardiovascular Systems

Myostatin regulates cardiomyocyte growth through modulation of Akt signaling

Michael R. Morissette et al.

CIRCULATION RESEARCH (2006)

Article Endocrinology & Metabolism

Myostatin is a human placental product that regulates glucose uptake

MD Mitchell et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Endocrinology & Metabolism

Myofibrillar protein synthesis in myostatin-deficient mice

S Welle et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)

Article Biochemistry & Molecular Biology

Ovarian theca cell

DA Magoffin

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)

Article Cell Biology

Regulation of GDF-8 signaling by the p38 MAPK

B Philip et al.

CELLULAR SIGNALLING (2005)

Review Endocrinology & Metabolism

Antagonists of activin signaling: mechanisms and potential biological applications

CA Harrison et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2005)

Article Medicine, General & Internal

Brief report -: Myostatin mutation associated with gross muscle hypertrophy in a child

M Schuelke et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Review Cell Biology

Regulation of muscle mass by myostatin

SJ Lee

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2004)

Article Cell Biology

Differential actions of follistatin and follistatin-like 3

A Schneyer et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2004)

Article Biochemistry & Molecular Biology

Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis

A Rebbapragada et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Endocrinology & Metabolism

Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression

K Ma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)

Article Obstetrics & Gynecology

Endometrial expression and secretion of activin A, but not follistatin, increase in the secretory phase of the menstrual cycle

P Florio et al.

JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2003)

Article Biology

Analysis of myostatin gene structure, expression and function in zebrafish

C Xu et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Myostatin inhibits myoblast differentiation by down-regulating MyoD expression

B Langley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Nutrition & Dietetics

Regulation of placental nutrient transport and implications for fetal growth

AW Bell et al.

NUTRITION RESEARCH REVIEWS (2002)

Review Obstetrics & Gynecology

Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review

A Delvigne et al.

HUMAN REPRODUCTION UPDATE (2002)

Article Biochemistry & Molecular Biology

The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum

JJ Hill et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Endocrinology & Metabolism

Gestational diabetes and the incidence of type 2 diabetes - A systematic review

C Kim et al.

DIABETES CARE (2002)

Review Medicine, General & Internal

Mechanisms of disease - Implantation and the survival of early pregnancy.

ER Norwitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Review Medicine, Research & Experimental

Steroidogenic acute regulatory protein: An update on its regulation and mechanism of action

LK Christenson et al.

ARCHIVES OF MEDICAL RESEARCH (2001)

Article Biochemistry & Molecular Biology

The two myostatin genes of Atlantic salmon (Salmo salar) are expressed in a variety of tissues

TK Ostbye et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)

Article Multidisciplinary Sciences

Regulation of myostatin activity and muscle growth

SJ Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Regulation of myostatin by glucocorticoids after thermal injury

CH Lang et al.

FASEB JOURNAL (2001)

Article Endocrinology & Metabolism

Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells

WE Taylor et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2001)