Psammosilenin C, a New Cyclic Peptide from Psammosilene tunicoides

Phytochemical investigation of Psammosilene tunicoides led to isolation of a new cyclicpeptide, psammosilenin C (1) and three known compounds, 1-O-(ss-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(2R)-2hydroxypentadecanoylamino]-4,8-octadecadiene-1,3-diol (2), dihydroferulic acid (3) and vanillylacetone (4). Their structures were elucidated by comprehensive spectroscopic methods, including 1D and 2D NMR spectroscopic, and HR-ESI-MS spectrometric data. Compounds 1, 2 and 4 showed inhibitory activities on lipopolysaccharide (LPS)-induced NO release in RAW 264.7 cells.

Automated summary

A phytochemical investigation of Psammosilene tunicoides led to the discovery of a new cyclic peptide compound and three known compounds. The structures of these compounds were elucidated using comprehensive spectroscopic methods, and it was found that some of these compounds exhibited inhibitory activities on the release of NO in cells.