Myrrhalindenane C, a New Eudesmane Sesquiterpenoid From Lindera Myrrha Roots

Phytochemical investigation of Lindera myrrha roots growing in Vietnam afforded a new eudesmane sesquiterpenoid, myrrhalindenane C (1), along with seven known compounds, rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid (2), 1-O-(4-hydroxy-2,6dimethoxyphenoxy)-6-O-[rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoyl]-beta-D-glucopyranose (3), curcumin (4), demethoxycurcumin (5), bisdemethoxycurcumin (6), (1E,6E)-1,7-bis(4-methoxyphenyl)-1,6-heptadiene-3,5-dione (7), and sanjoseolide (8). The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. All compounds were evaluated for antimicrobial activity against antibiotic-resistant, pathogenic bacteria Enterococcus faecium, Staphylococcus aureus, and Acinetobacter baumannii.

Automated summary

A phytochemical investigation of Lindera myrrha roots growing in Vietnam led to the discovery of a new eudesmane sesquiterpenoid compound, along with seven known compounds. These compounds exhibited antimicrobial activity against antibiotic-resistant, pathogenic bacteria.