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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)
Mitochondrial function in hypoxic ischemic injury and influence of aging
P. Benson Ham et al.
PROGRESS IN NEUROBIOLOGY (2017)
CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons
Xiaobing Qing et al.
STEM CELL RESEARCH (2017)
Cytosolic Proteostasis Networks of the Nlitochondrial Stress Response
Davide D'Amico et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease
Amit U. Joshi et al.
Oncotarget (2017)
Application of calibrated fMRI in Alzheimer's disease
Isabelle Lajoie et al.
NEUROIMAGE-CLINICAL (2017)
Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons
Andrew J. Schwab et al.
STEM CELL REPORTS (2017)
Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinsons Disease Patients
Patrik Krumpolec et al.
FRONTIERS IN NEUROLOGY (2017)
Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease
Wenbo Zhou et al.
PLOS ONE (2017)
Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles
Kai-C. Sonntag et al.
SCIENTIFIC REPORTS (2017)
Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
Heather J. Weir et al.
CELL METABOLISM (2017)
Ageing and hypoxia cause protein aggregation in mitochondria
Daniel M. Kaufman et al.
CELL DEATH AND DIFFERENTIATION (2017)
Interaction of misfolded proteins and mitochondria in neurodegenerative disorders
Andrey Y. Abramov et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2017)
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production
Victor Tapias et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Interactions of pathological proteins in neurodegenerative diseases
Tara L. Spires-Jones et al.
ACTA NEUROPATHOLOGICA (2017)
α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production
Sebastien Paillusson et al.
ACTA NEUROPATHOLOGICA (2017)
Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons
Sadafumi Suzuki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic Change
Eun-Joo Shin et al.
MOLECULAR NEUROBIOLOGY (2016)
An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology
Natalia A. Stefanova et al.
AGING-US (2016)
Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons
Anne Gruenewald et al.
ANNALS OF NEUROLOGY (2016)
Screening for chemical modulators for LRRK2
Heather Mortiboys
BIOCHEMICAL SOCIETY TRANSACTIONS (2016)
Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis
Dah Ihm Kim et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)
Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease
T. C. Bernardo et al.
BRAIN PATHOLOGY (2016)
Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death
Xiaonan Wang et al.
BRAIN RESEARCH (2016)
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Juliana Camacho-Pereira et al.
CELL METABOLISM (2016)
Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease
Chung-Han Hsieh et al.
CELL STEM CELL (2016)
Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease
John S. Beck et al.
CURRENT ALZHEIMER RESEARCH (2016)
The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR
Christopher J. Fiorese et al.
CURRENT BIOLOGY (2016)
Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes
Paul S. Baxter et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease
Xiangling Yin et al.
HUMAN MOLECULAR GENETICS (2016)
Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions
Sara Martire et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Protective effects of a natural product, curcumin, against amyloid β induced mitochondrial and synaptic toxicities in Alzheimer's disease
P. Hemachandra Reddy et al.
JOURNAL OF INVESTIGATIVE MEDICINE (2016)
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
Marthe H. R. Ludtmann et al.
JOURNAL OF NEUROSCIENCE (2016)
Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice
Yunhua Peng et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2016)
Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
W. P. Vermeij et al.
NATURE (2016)
Correcting mitochondrial fusion by manipulating mitofusin conformations
Antonietta Franco et al.
NATURE (2016)
Mitonuclear communication in homeostasis and stress
Pedro M. Quiros et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease
Angela Pyle et al.
NEUROBIOLOGY OF AGING (2016)
Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics
Jing Jin et al.
NEUROMOLECULAR MEDICINE (2016)
Mitochondrial Alterations in Peripheral Mononuclear Blood Cells from Alzheimer's Disease and Mild Cognitive Impairment Patients
A. Delbarba et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
How neuroinflammation contributes to neurodegeneration
Richard M. Ransohoff
SCIENCE (2016)
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease
Roberto Di Maio et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease
Simon J. Beck et al.
NATURE COMMUNICATIONS (2016)
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
Christian Dolle et al.
NATURE COMMUNICATIONS (2016)
Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins
Xia-Chun Li et al.
SCIENTIFIC REPORTS (2016)
Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects
Y. Kim et al.
TRANSLATIONAL PSYCHIATRY (2016)
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation
Sun Young Chung et al.
STEM CELL REPORTS (2016)
Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
Yannis Gerakis et al.
SCIENTIFIC REPORTS (2016)
Curcumin/Melatonin Hybrid 5-(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model
Gorka Gerenu et al.
ACS CHEMICAL NEUROSCIENCE (2015)
Reduced Cerebrospinal Fluid Mitochondrial DNA Is a Biomarker for Early-Stage Parkinson's Disease
Angela Pyle et al.
ANNALS OF NEUROLOGY (2015)
Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model
Eran Blacher et al.
ANNALS OF NEUROLOGY (2015)
Dietary restriction, mitochondrial function and aging: from yeast to humans
Andrea Ruetenik et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)
Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat
Laura E. Clemens et al.
BRAIN (2015)
Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu
Sonia C. Correia et al.
DNA AND CELL BIOLOGY (2015)
Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains
Xuan Ye et al.
HUMAN MOLECULAR GENETICS (2015)
Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease
Moon-Yong Cha et al.
HUMAN MOLECULAR GENETICS (2015)
Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells
Junghyung Park et al.
JOURNAL OF NEUROCHEMISTRY (2015)
Abnormalities in the Tricarboxylic Acid Cycle in Huntington Disease and in a Huntington Disease Mouse Model
Nima N. Naseri et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2015)
Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis
Thibaud T. Renault et al.
MOLECULAR CELL (2015)
Mitochondrial DNA stress primes the antiviral innate immune response
A. Phillip West et al.
NATURE (2015)
Blockage of GSK3 beta-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease
Jing Yan et al.
NEUROBIOLOGY OF AGING (2015)
Triheptanoin improves brain energy metabolism in patients with Huntington disease
Isaac Mawusi Adanyeguh et al.
NEUROLOGY (2015)
EXERCISE TRAINING NORMALIZES MITOCHONDRIAL RESPIRATORY CAPACITY WITHIN THE STRIATUM OF THE R6/1 MODEL OF HUNTINGTON'S DISEASE
E. A. F. Herbst et al.
NEUROSCIENCE (2015)
Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease
Asako Yoritaka et al.
PARKINSONISM & RELATED DISORDERS (2015)
Higd1a is a positive regulator of cytochrome c oxidase
Takaharu Hayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
SARM1 activation triggers axon degeneration locally via NAD+ destruction
Josiah Gerdts et al.
SCIENCE (2015)
Neuroprotective effects of dietary restriction: Evidence and mechanisms
Giovambattista Pani
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)
PINK1-induced mitophagy promotes neuroprotection in Huntington's disease
B. Khalil et al.
CELL DEATH & DISEASE (2015)
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
A. K. Reeve et al.
CELL DEATH & DISEASE (2015)
N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease
D. J. Wright et al.
TRANSLATIONAL PSYCHIATRY (2015)
Mitochondrial dynamics and mitochondrial quality control
Hong-Min Ni et al.
REDOX BIOLOGY (2015)
PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
Carine Ciron et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington's Disease Human Lymphoblasts
Luana Naia et al.
MOLECULAR NEUROBIOLOGY (2015)
Melatonin Attenuates Memory Impairment, Amyloid-beta Accumulation, and Neurodegeneration in a Rat Model of Sporadic Alzheimer's Disease
Ekaterina A. Rudnitskaya et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson's disease symptoms without side effects
Chandramohan Wakade et al.
CLINICAL CASE REPORTS (2015)
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
Xinglong Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell
Xueqi Gan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
MITOHORMESIS: PROMOTING HEALTH AND LIFESPAN BY INCREASED LEVELS OF REACTIVE OXYGEN SPECIES (ROS)
Michael Ristow et al.
DOSE-RESPONSE (2014)
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease
Brent J. Ryan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ (1-42)-induced rat model of Alzheimer's disease
E. Turunc Bayrakdar et al.
FREE RADICAL RESEARCH (2014)
Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's Disease
David Porquet et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Mitochondrial DNA Copy Numbers in Pyramidal Neurons are Decreased and Mitochondrial Biogenesis Transcriptome Signaling is Disrupted in Alzheimer's Disease Hippocampi
Ann C. Rice et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction
Eric S. Luth et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease
Virginija Jovaisaite et al.
JOURNAL OF EXPERIMENTAL BIOLOGY (2014)
Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease
Carmen Noelker et al.
JOURNAL OF NEUROINFLAMMATION (2014)
The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation
Yvette C. Wong et al.
JOURNAL OF NEUROSCIENCE (2014)
Proteomics of Huntington's Disease-Affected Human Embryonic Stem Cells Reveals an Evolving Pathology Involving Mitochondrial Dysfunction and Metabolic Disturbances
Leon R. McQuade et al.
JOURNAL OF PROTEOME RESEARCH (2014)
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
Odochi Ohia-Nwoko et al.
MOLECULAR NEURODEGENERATION (2014)
Inhibition of mitochondrial protein import by mutant huntingtin
Hiroko Yano et al.
NATURE NEUROSCIENCE (2014)
The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice
Lee J. Martin et al.
NEUROBIOLOGY OF AGING (2014)
Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons
Rodrigo A. Quintanilla et al.
NEUROBIOLOGY OF DISEASE (2014)
Effects of Long-Term Treatment with Quercetin on Cognition and Mitochondrial Function in a Mouse Model of Alzheimer's Disease
Dong-Mei Wang et al.
NEUROCHEMICAL RESEARCH (2014)
Exercise-Induced Neuroprotection of Hippocampus in APP/PS1 Transgenic Mice via Upregulation of Mitochondrial 8-Oxoguanine DNA Glycosylase
Hai Bo et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)
Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication
Adrian Flierl et al.
PLOS ONE (2014)
High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice
S-Y Kook et al.
CELL DEATH & DISEASE (2014)
Low Cerebrospinal Fluid Concentration of Mitochondrial DNA in Preclinical Alzheimer Disease
Petar Podlesniy et al.
ANNALS OF NEUROLOGY (2013)
The protective effect of hyperbaric oxygen and Ginkgo biloba extract on Aβ25-35-induced oxidative stress and neuronal apoptosis in rats
XiaoQiang Tian et al.
BEHAVIOURAL BRAIN RESEARCH (2013)
Mitochondrial fission-fusion as an emerging key regulator of cell proliferation and differentiation
Kasturi Mitra
BIOESSAYS (2013)
Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington's disease-like rat model
Inmaculada Tasset et al.
BRAIN STIMULATION (2013)
Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency
Sara Cogliati et al.
CELL (2013)
Isogenic Human iPSC Parkinson's Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Scott D. Ryan et al.
CELL (2013)
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Brendan Egan et al.
CELL METABOLISM (2013)
Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model
Marcio Lazzarini et al.
GLIA (2013)
Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntingtons disease
Eleonora Napoli et al.
HUMAN MOLECULAR GENETICS (2013)
A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin
Maria Damiano et al.
HUMAN MOLECULAR GENETICS (2013)
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration
Xing Guo et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic Huntington's disease carriers
Ana C. Silva et al.
MITOCHONDRION (2013)
Mitonuclear protein imbalance as a conserved longevity mechanism
Riekelt H. Houtkooper et al.
NATURE (2013)
Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
Bing Gong et al.
NEUROBIOLOGY OF AGING (2013)
Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession
Dong Liu et al.
NEUROBIOLOGY OF AGING (2013)
TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease
Andreas Bender et al.
PLOS ONE (2013)
The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against A beta Plaque Pathology
Cristina Grossi et al.
PLOS ONE (2013)
Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
Louise Hedskog et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease
Michael T. Lin et al.
ANNALS OF NEUROLOGY (2012)
The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease
Peter Bai et al.
CELL METABOLISM (2012)
Shaping the role of mitochondria in the pathogenesis of Huntington's disease
Veronica Costa et al.
EMBO JOURNAL (2012)
Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntingtons disease
Ashu Johri et al.
HUMAN MOLECULAR GENETICS (2012)
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease
Ulziibat P. Shirendeb et al.
HUMAN MOLECULAR GENETICS (2012)
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimers disease neurons: implications for mitochondrial dysfunction and neuronal damage
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2012)
Mitochondria-targeted catalase reduces abnormal APP processing, amyloid production and BACE1 in a mouse model of Alzheimers disease: implications for neuroprotection and lifespan extension
Peizhong Mao et al.
HUMAN MOLECULAR GENETICS (2012)
Behavioral Improvement after Chronic Administration of Coenzyme Q10 in P301S Transgenic Mice
Ceyhan Elipenahli et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Overexpression of Amyloid-β Protein Precursor Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptotic Cascade
Matthew G. Bartley et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease
Baiyang Sheng et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Coenzyme Q10 deficiency in patients with Parkinson's disease
Laurie K. Mischley et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)
Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer's Disease
Barbara Biscaro et al.
NEURODEGENERATIVE DISEASES (2012)
N-Acetylcysteine Reverses Mitochondrial Dysfunctions and Behavioral Abnormalities in 3-Nitropropionic Acid-Induced Huntington's Disease
Rajat Sandhir et al.
NEURODEGENERATIVE DISEASES (2012)
Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death
Moon-Yong Cha et al.
PLOS ONE (2012)
Correction: Microtubule Destabilization Is Shared by Genetic and Idiopathic Parkinson’s Disease Patient Fibroblasts
Daniele Cartelli et al.
PLoS One (2012)
Amyloid-β Peptide Binds to Cytochrome C Oxidase Subunit 1
Luis Fernando Hernandez-Zimbron et al.
PLOS ONE (2012)
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease
Hector De Jesus-Cortes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms
Ines Marques-Aleixo et al.
PROGRESS IN NEUROBIOLOGY (2012)
Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Oliver Cooper et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Characterization of Mitophagy in the 6-Hydoxydopamine Parkinson's Disease Model
Maria E. Solesio et al.
TOXICOLOGICAL SCIENCES (2012)
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
Yoichi Imaizumi et al.
MOLECULAR BRAIN (2012)
Impaired Complex-I Mitochondrial Biogenesis in Parkinson Disease Frontal Cortex
Ravindar R. Thomas et al.
JOURNAL OF PARKINSONS DISEASE (2012)
Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons
Marcus J. Calkins et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)
Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning
Gregg L. Semenza
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity
Jenni Durieux et al.
CELL (2011)
Role of Sirtuins and Calorie Restriction in Neuroprotection: Implications in Alzheimer's and Parkinson's Diseases
Sarika Srivastava et al.
CURRENT PHARMACEUTICAL DESIGN (2011)
Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
Jean-Claude Martinou et al.
DEVELOPMENTAL CELL (2011)
Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease
Marie Westerlund et al.
FASEB JOURNAL (2011)
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2011)
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
Ulziibat Shirendeb et al.
HUMAN MOLECULAR GENETICS (2011)
Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer's Disease
Magali Dumont et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Signaling of Glial Cell Line-Derived Neurotrophic Factor and Its Receptor GFRα1 Induce Nurr1 and Pitx3 to Promote Survival of Grafted Midbrain-Derived Neural Stem Cells in a Rat Model of Parkinson Disease
Zhinian Lei et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)
Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells
Philip Seibler et al.
JOURNAL OF NEUROSCIENCE (2011)
The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
Meagan J. McManus et al.
JOURNAL OF NEUROSCIENCE (2011)
Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling
Natasa Dragicevic et al.
JOURNAL OF PINEAL RESEARCH (2011)
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
Wenjun Song et al.
NATURE MEDICINE (2011)
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology
Karim Belarbi et al.
NEUROBIOLOGY OF DISEASE (2011)
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
Wencheng Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
Veronica Costa et al.
EMBO MOLECULAR MEDICINE (2010)
Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington's disease
Fanny Mochel et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2010)
Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease
Jinho Kim et al.
HUMAN MOLECULAR GENETICS (2010)
Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia
Pinar E. Coskun et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition
Virginie Loeb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Perturbations in Mitochondrial Dynamics Induced by Human Mutant PINK1 Can Be Rescued by the Mitochondrial Division Inhibitor mdivi-1
Mei Cui et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Transcranial direct current stimulation for the treatment of Parkinson's disease
David H. Benninger et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2010)
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
Marta Martinez-Vicente et al.
NATURE NEUROSCIENCE (2010)
Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system
Rajat Sandhir et al.
NEUROCHEMISTRY INTERNATIONAL (2010)
Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1
Guido Krebiehl et al.
PLOS ONE (2010)
PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease
Bin Zheng et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology
A. Gruenewald et al.
EXPERIMENTAL NEUROLOGY (2009)
Effects of overexpression of Huntingtin proteins on mitochondrial integrity
Hongmin Wang et al.
HUMAN MOLECULAR GENETICS (2009)
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