Journal
JOURNAL OF DERMATOLOGY
Volume 43, Issue 12, Pages 1429-1432Publisher
WILEY-BLACKWELL
DOI: 10.1111/1346-8138.13516
Keywords
lactate dehydrogenase; lactate dehydrogenase-M subunit deficiency; nicotinamide adenine dinucleotide; pellagra; pustular psoriasis
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Hereditary lactate dehydrogenase (LDH) M-subunit deficiency is very rare and we have found reports of close to a dozen cases in the published work, two of which were associated with pustular psoriasis-like lesions. We report a third case of pustular psoriasis-like eruptions associated with LDH M-subunit deficiency, which occurred 24 years after the diagnosis of LDH M-subunit deficiency. These cases indicate that abnormal activity of LDH can induce pustular psoriatic lesions in the long term. Some patients with symptoms of hereditary LDH M-subunit deficiency have antecedent annular scaly plaque lesions, that resemble psoriatic lesions. We discuss a hypothesis to explain this scenario.
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