Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 32, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2116895119
Keywords
interneurons; cortical circuits; sensory deprivation; synaptic plasticity; network model
Categories
Funding
- Max Planck Society
- European Research Council under the European Union's Horizon 2020 research and innovation program [804824]
- Deutsche Forschungsgemeinschaft
- European Research Council (ERC) [804824] Funding Source: European Research Council (ERC)
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This study investigates the impact of deprivation-induced synaptic changes on excitatory and inhibitory firing rates. It reveals that a single interneuron subtype can only co-modulate the firing rates together, while independent modulation observed in experiments requires strong feedback from a second interneuron subtype.
Diverse interneuron subtypes shape sensory processing in mature cortical circuits. During development, sensory deprivation evokes powerful synaptic plasticity that alters circuitry, but how different inhibitory subtypes modulate circuit dynamics in response to this plasticity remains unclear. We investigate how deprivation-induced synaptic changes affect excitatory and inhibitory firing rates in a microcircuit model of the sensory cortex with multiple interneuron subtypes. We find that with a single interneuron subtype (parvalbumin-expressing [PV]), excitatory and inhibitory firing rates can only be comodulated-increased or decreased together. To explain the experimentally observed independent modulation, whereby one firing rate increases and the other decreases, requires strong feedback from a second interneuron subtype (somatostatin-expressing [SST]). Ourmodel applies to the visual and somatosensory cortex, suggesting a general mechanism across sensory cortices. Therefore, we provide a mechanistic explanation for the differential role of interneuron subtypes in regulating firing rates, contributing to the already diverse roles they serve in the cortex.
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