Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 32, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2201578119
Keywords
knowledge assimilation; idling brain; engram; sleep; implicit learning
Categories
Funding
- Japan Society For the Promotion of Science (JSPS) [JP18H05213]
- Core Research for Evolutional Science and Technology program of the Japan Science and Technology Agency [JPMJCR13W1]
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) [JP25115002]
- Takeda Science Foundation
- Uehara Memorial Foundation
- JSPS KAKENHI [JP19K16892, JP20H03554, JP17K19445]
- Hokuriku Bank
- Firstbank of Toyama Scholarship Foundation Research Grant
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The passive priming of prior knowledge to assimilate ongoing experiences is essential for advanced cognitive processing. This study investigates the neural dynamics of memory assimilation and the potential creativity of the idling brain. The findings suggest that assimilating pertinent memories through coreactivation during sleep represents the neural underpinnings of sleep-triggered implicit cortical learning.
Passive priming of prior knowledge to assimilate ongoing experiences underlies advanced cognitive processing. However, the necessary neural dynamics of memory assimilation remains elusive. Uninstructed brain could also show boosted creativity, particularly after idling states, yet it remains unclear whether the idling brain can spontaneously spark relevant knowledge assimilations. We established a paradigm that links/separates context-dependent memories according to geometrical similarities. Mice exploring one of four contexts 1 d before undergoing contextual fear conditioning in a square context showed a gradual fear transfer to preexposed geometrically relevant contexts the next day, but not after 15 min. Anterior cingulate cortex neurons representing relevant, rather than distinct, memories were significantly coreactivated during postconditioning sleep only, before their selective integration the next day during testing. Disrupting sleep coreactivations prevented assimilation while preserving recent memory consolidation. Thus, assimilating pertinent memories during sleep through coreactivation of their respective engrams represents the neural underpinnings of sleep-triggered implicit cortical learning.
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