Treatment effect of Co(II)-coordination polymers on postpartum depression by regulating 5-HT content

Two coordination polymers (CPs) on the basis of Co(II) have been prepared with or without a nitrogen-donor ligand bipyridine under the conditions of solvothermal, with the chemical formula of {[Co-3(IDPA)(3)(DMA)(H2O)(2)]center dot(H2O)(DMA)}n (1, where DMA is N,N-dimethylacetamide, bpy is bipyridine, and H(2)IDPA is 5-(1-oxoisoindolin-2-yl) isophthalic acid) and [Co(IDPA)(4,4 '-bpy)(1/2)](n) (2). Furthermore, the treatment effect of compounds on postpartum depression was assessed and the corresponding mechanism was also investigated. The analysis of enzyme linked immunosorbent assay was applied for testing the progesterone and 5-hydroxytryptamine (5-HT) content in the brain after indicated compound treatment. After that the progesterone and 5-HT relative expression was assessed with the analysis of real-time reverse transcription-polymerase chain reaction. The experimental results show that CP 1 was much powerful than 2 on attenuating the contents of progesterone and 5-HT exist in brain. Besides this, the progesterone and 5-HT receptor relative expression on neurons was also markedly attenuated by CP 1, instead of 2.

Automated summary

In this study, two coordination polymers based on Co(II) were synthesized using solvothermal method, with different nitrogen-donor ligands. The treatment effect of these compounds on postpartum depression was assessed, and the underlying mechanism was investigated.