Synthetic Utility of Bis-Aminomercapto[1,2,4] Triazoles in the Preparation of Bis- Fused Triazoles and Macrocycles

The current review presents recent progress in the synthetic utility of bis-(4-amino-5-mercapto[1,2,4] triazoles) as building blocks for a diverse range of bis-fused [1,2,4]triazoles such as; bis-(triazolo-thiadiazoles), bis(triazolo-thiadiazines), bis(triazolo-thiadiazepines), and polymeric materials with pharmacological interest. Also, synthesis of macrocycles, containing [1,2,4]triazole subunits were demonstrated. All of these topics are drawn in this review during the period from 2000 to February 2022.

Automated summary

This recent review highlights the synthetic utility of bis-(4-amino-5-mercapto[1,2,4] triazoles) as versatile building blocks for the synthesis of diverse bis-fused [1,2,4]triazoles and pharmacological polymeric materials. The synthesis of macrocycles containing [1,2,4]triazole subunits is also demonstrated. The review encompasses the period from 2000 to February 2022.