Effects of day-to-day variation of Opisthorchis viverrini antigen in urine on the accuracy of diagnosing opisthorchiasis in Northeast Thailand

Article Urology & Nephrology

Association between Opisthorchis viverrini Infection and Glomerular Disease in Thailand

Pantipa Tonsawan et al.

Summary: This study is the first to demonstrate the presence of Opisthorchis viverrini (OV) antigen in human kidney tissue, suggesting a possible association between OV infection and biopsy-proven glomerular diseases.

AMERICAN JOURNAL OF NEPHROLOGY (2022)

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Article Spectroscopy

A fluorescence AuNPs-LISA: A new approach for Opisthorchis viverrini (Ov) antigen detection with a simple fluorescent enhancement strategy by surfactant micelle in urine samples

Wichit Taron et al.

Summary: The development of a new fluorescence AuNPs-LISA technique utilizing OPD as a chromogenic substrate and incorporating the non-ionic surfactant Triton X-100 has significantly enhanced the detection sensitivity for OvAg concentration, leading to a 1200-fold improvement compared to the colorimetric AuNPs-LISA. The proposed assay demonstrates high diagnosis sensitivity, specificity, and accuracy, providing a promising tool for the detection, control, and elimination of human opisthorchiasis in endemic areas.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Review Parasitology

Towards Evidence-based Control of Opisthorchis viverrini

Thomas Crellen et al.

Summary: This article discusses the ongoing transmission of the carcinogenic liver fluke Opisthorchis viverrini in Southeast Asia, the different stages of control in endemic countries within the region, and the lack of evidence on effective interventions for reducing parasite transmission and liver cancer. The use of quantitative modeling to evaluate control measures and assist in designing clinical trials is proposed as a way to develop evidence-based strategies for parasite control at a national or regional level.

TRENDS IN PARASITOLOGY (2021)

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Article Biochemical Research Methods

Opisthorchis viverrini Infection Induces Metabolic and Fecal Microbial Disturbances in Association with Liver and Kidney Pathologies in Hamsters

Ornuma Haonon et al.

Summary: Opisthorchis viverrini infection causes hepatobiliary diseases and is a major risk factor for cholangiocarcinoma. The infection leads to disturbances in host amino acid metabolism, TCA cycle, liver, and kidney pathologies, as well as changes in fecal microbial composition and urinary host-microbial cometabolism.

JOURNAL OF PROTEOME RESEARCH (2021)

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Article Chemistry, Analytical