4.6 Article

Magnesium impairs Candida albicans immune evasion by reduced hyphal damage, enhanced β-glucan exposure and altered vacuole homeostasis

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Insights into the modulatory effect of magnesium on efflux mechanisms of Candida albicans reveal inhibition of ATP binding cassette multidrug transporters and dysfunctional mitochondria

Sandeep Hans et al.

Summary: This study investigated the impact of magnesium deprivation on efflux pump activity in Candida albicans, revealing that magnesium deprivation inhibits ABC superfamily transporters and causes mislocalization of efflux pumps. Additionally, magnesium deprivation reduces ergosterol content, impairs mitochondrial potential, and may lead to decreased efflux activity, suggesting it as a potential antifungal strategy against multidrug resistance.

BIOMETALS (2021)

Article Multidisciplinary Sciences

Immune cells fold and damage fungal hyphae

Judith M. Bain et al.

Summary: Innate immunity is vital in protecting against fungal infections, but pathogens have evolved ways to evade immune cells. Researchers found that macrophages can counteract pathogen evasion by folding fungal hyphae, promoting successful fungal clearance through engulfment and inhibition of hyphal growth.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cell Biology

The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans

Nicola T. Case et al.

Summary: Host protein PTMA is identified as a component of macrophage lysate that induces filamentation in Candida albicans, adding to the known triggers of fungal escape from immune cells.

CELL REPORTS (2021)

Article Microbiology

Activation of Cph1 causes ss(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner

Andrew S. Wagner et al.

Summary: Activation of the Cek1 MAPK pathway and unmasking of immunogenic cell wall epitope ss(1,3)-glucan by specific genetic mutations weaken the virulence of Candida albicans. Neutrophils play a critical role in the clearance of unmasked fungal cells.

PLOS PATHOGENS (2021)

Review Microbiology

Revisiting the Vital Drivers and Mechanisms of β-Glucan Masking in Human Fungal Pathogen, Candida albicans

Saif Hameed et al.

Summary: Candida genus is a common human fungal pathogen with complex cell wall and the ability to mask immunogenic molecules, contributing to its virulence. Understanding the masking mechanism of Candida can lead to the identification of new antifungal targets and improve therapeutic approaches for candidiasis.

PATHOGENS (2021)

Review Microbiology

The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species

Rocio Garcia-Rubio et al.

FRONTIERS IN MICROBIOLOGY (2020)

Review Cell Biology

Pattern recognition receptors in fungal immunity

Emmanuel C. Patin et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

Article Multidisciplinary Sciences

Alcohol dehydrogenase of Candida albicans triggers differentiation of THP-1 cells into macrophages

Yanglan Liu et al.

JOURNAL OF ADVANCED RESEARCH (2019)

Article Microbiology

Dependence on Dectin-1 Varies With Multiple Candida Species

Aiysha Thompson et al.

FRONTIERS IN MICROBIOLOGY (2019)

Article Infectious Diseases

Magnesium deprivation affects cellular circuitry involved in drug resistance and virulence in Candida albicans

Sandeep Hans et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2019)

Review Microbiology

Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis

Liliana Scorzoni et al.

FRONTIERS IN MICROBIOLOGY (2017)

Article Immunology

Interaction of THP-1 Monocytes with Conidia and Hyphae of Different Curvularia Strains

Eszter Judit Toth et al.

FRONTIERS IN IMMUNOLOGY (2017)

Review Microbiology

Interactions of fungal pathogens with phagocytes

Lars P. Erwig et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Review Physiology

MAGNESIUM IN MAN: IMPLICATIONS FOR HEALTH AND DISEASE

Jeroen H. F. de Baaij et al.

PHYSIOLOGICAL REVIEWS (2015)

Article Multidisciplinary Sciences

Global analysis of fungal morphology exposes mechanisms of host cell escape

Teresa R. O'Meara et al.

NATURE COMMUNICATIONS (2015)

Review Immunology

Immune defence against Candida fungal infections

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Microbiology

Quinacrine Inhibits Candida albicans Growth and Filamentation at Neutral pH

Vibhati V. Kulkarny et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Article Biochemistry & Molecular Biology

V-ATPase-dependent luminal acidification is required for endocytic recycling of a yeast cell wall stress sensor, Wsc1p

Kazuma Ueno et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Essential Role for Vacuolar Acidification in Candida albicans Virulence

Cassandra Patenaude et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

The V-ATPase as a Target for Antifungal Drugs

Yongqiang Zhang et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2012)

Review Cell Biology

Hidden Killers: Human Fungal Infections

Gordon D. Brown et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Article Immunology

Nosocomial Fungal Infections: Epidemiology, Infection Control, and Prevention

George J. Alangaden

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2011)

Article Multidisciplinary Sciences

Regulation of Alr1 Mg Transporter Activity by Intracellular Magnesium

Phaik Har Lim et al.

PLOS ONE (2011)

Article Immunology

Beyond ergosterol: Linking pH to antifungal mechanisms

Yongqiang Zhang et al.

Virulence (2011)

Article Biotechnology & Applied Microbiology

Vacuolar dynamics during the morphogenetic transition in Candida albicans

Veronica Veses et al.

FEMS YEAST RESEARCH (2008)

Article Biophysics

The long physiological reach of the yeast vacuolar H+-ATPase

Patricia M. Kane

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2007)

Article Biochemistry & Molecular Biology

NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans

AMA Murad et al.

EMBO JOURNAL (2001)

Article Biochemistry & Molecular Biology

Yeast Lrg1p acts as a specialized RhoGAP regulating 1,3-β-glucan synthesis

D Watanabe et al.

YEAST (2001)