Detection of silent infection of severe acute respiratory syndrome coronavirus 2 by serological tests

Article Infectious Diseases

Prospective Sero-epidemiological Evaluation of SARS-CoV-2 among Health Care Workers in a German Secondary Care Hospital

Jonas Herzberg et al.

Summary: The study aimed to detect SARS-CoV-2 virus and specific antibodies among healthcare workers in a German hospital. The low prevalence of COVID-19 in healthcare workers may reflect the effectiveness of hygiene protocols, or indicate a low prevalence of SARS-CoV-2 among hospital employees.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

S. F. Lumley et al.

Summary: In a longitudinal study of seropositive and seronegative health care workers undergoing asymptomatic and symptomatic SARS-CoV-2 testing, the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms

Michael A. Johansson et al.

Summary: The study suggests that more than half of COVID-19 transmission may come from asymptomatic individuals, highlighting the importance of measures beyond identifying and isolating symptomatic cases in controlling the spread of the virus.

JAMA NETWORK OPEN (2021)

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Article Infectious Diseases

Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections

David W. Eyre et al.

Summary: This study evaluated quantitative IgG responses in a cohort of healthcare workers in Oxford, UK, finding that following mild SARS-CoV-2 infection, a certain percentage of individuals may have negative immunoassay results. This has implications for epidemiological analyses and result interpretation in individuals with a high pre-test probability.

BMC INFECTIOUS DISEASES (2021)

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News Item Multidisciplinary Sciences

OMICRON LIKELY TO WEAKEN COVID VACCINE PROTECTION

Ewen Callaway

NATURE (2021)

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Article Infectious Diseases

Seroprevalence of SARS-CoV-2 antibody among healthcare workers in a university hospital in Mallorca, Spain, during the first wave of the COVID-19 pandemic

Adrian Rodriguez et al.

Summary: The study aimed to estimate the SARS-CoV-2 antibody seroprevalence in healthcare workers at a university hospital in Mallorca, Spain. The results showed that after the first wave of the COVID-19 pandemic, the seroprevalence of SARS-CoV-2 antibodies in hospital HCWs was around 2.8%, slightly higher than the general population in the region. It is recommended to conduct additional seroprevalence studies during the second wave of the epidemic.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Microbiology

Clinical Evaluation of the Abbott Alinity SARS-CoV-2 Spike-Specific Quantitative IgG and IgM Assays among Infected, Recovered, and Vaccinated Groups

Madhusudhanan Narasimhan et al.

Summary: This study evaluated antibody responses in different populations after vaccination using new serological assays, demonstrating a significant increase in IgGSP and IgMSP values post vaccination.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Multidisciplinary Sciences

Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants

Amarendra Pegu et al.

Summary: The study assessed the impact of SARS-CoV-2 variants on antibody responses induced by the mRNA vaccine over 7 months, showing that most individuals maintained binding and functional antibodies against variants, with B.1.351 having the lowest antibody recognition.

SCIENCE (2021)

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Article Immunology

Detection of Anti-SARS-CoV-2-S2 IgG Is More Sensitive Than Anti-RBD IgG in Identifying Asymptomatic COVID-19 Patients

Baolin Liao et al.

Summary: Characterizing the serologic features of asymptomatic SARS-CoV-2 infection is crucial for diagnostics and control. This study found that asymptomatic infections exhibit weaker overall antibody responses, primarily inducing IgG antibody responses. Anti-S2-IgG shows better sensitivity in identifying asymptomatic infections early after infection compared to anti-RBD-IgG.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Microbiology

Serological Testing Reveals the Hidden COVID-19 Burden among Health Care Workers Experiencing a SARS-CoV-2 Nosocomial Outbreak

Yu Nakagama et al.

Summary: The study conducted antibody testing on healthcare workers in a Japanese hospital that experienced a COVID-19 outbreak, revealing that 42% of overlooked COVID-19 diagnoses occurred when case detection relied solely on PCR-based viral detection. Exposures to specific aerosol-generating procedures were found to mediate transmission. The findings support a multi-tiered testing approach, including serological diagnostics, for comprehensive case detection of COVID-19.

MICROBIOLOGY SPECTRUM (2021)

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Article Biology