Journal
PITUITARY
Volume 25, Issue 5, Pages 693-697Publisher
SPRINGER
DOI: 10.1007/s11102-022-01249-5
Keywords
Cortisol; Adrenal; Pituitary; Cushing's disease; UFC; DST
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Diagnosis of Cushing's syndrome is often delayed due to its rarity and variable clinical features. Simple and accurate screening tests, such as overnight dexamethasone suppression test and urinary free cortisol test, are necessary to enhance screening for hypercortisolism.
Diagnosis of Cushing's syndrome (CS) is often delayed due to variable clinical features and its rarity. Simple and accurate screening tests are required to enhance screening for hypercortisolism. Both overnight 1 mg dexamethasone suppression test (DST) and urinary free cortisol (UFC) demonstrate high sensitivity and specificity for the diagnosis of CS. However, each test has its own distinctive features, making it preferable in specific clinical conditions. This review will discuss the pitfalls for each of those tests.
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