☆ 4.7 Article

High-quality trials and pharmacological studies needed as translational evidence for the application of traditional Chinese medicine Lianhua Qingwen against COVID-19

PHYTOTHERAPY RESEARCH (2022)

Related references

Note: Only part of the references are listed.

Review Biochemistry & Molecular Biology

Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research

Da-Cheng Hao et al.

Summary: In this study, the DMPK attributes of representative anti-COVID-19 herbs were critically examined and discussed. The extracts and compounds of these herbs show distinct ADME/T properties. Herb-herb interactions and herb-drug interactions have a significant impact on the PK/PD performance of the compounds. DMPK studies should be extended to more compounds and different medicinal parts, species, and formulations.

CURRENT DRUG METABOLISM (2022)

Add to Collection

Article Plant Sciences

Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial

Ke Hu et al.

Summary: The study found that the use of LH capsules in treating patients with Covid-19 significantly improved the symptom recovery rate, shortened the time to symptom relief, and had positive effects on the patients' imaging manifestations and clinical cure rate.

PHYTOMEDICINE (2021)

Add to Collection

Article Pharmacology & Pharmacy

Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening

Xiaofei Chen et al.

Summary: This study confirms the effectiveness of Lianhuaqingwen (LHQW) capsule in treating COVID-19 pneumonia, providing chemical and biochemical evidence for exploring its therapeutic effects based on human exposure to its components and pharmacological activities. It demonstrates the utility of the human exposure-based approach in identifying pharmaceutically active components in Chinese herb medicines.

ACTA PHARMACEUTICA SINICA B (2021)

Add to Collection

Article Cell Biology

New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment

Zhao Tianyu et al.

Aging-US (2021)

Add to Collection

Review Plant Sciences

Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts

Zhonglei Wang et al.

Summary: Traditional Chinese herbal medicines have shown promising potential for treating COVID-19, including active ingredients, monomer preparations, crude extracts, and formulas, all of which have potential activity against SARS-CoV-2 and have shown significant effects both in vitro and in clinical practice. As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Add to Collection

Article Integrative & Complementary Medicine

Efficacy and Safety of Lianhuaqingwen Capsules for the Prevention of Coronavirus Disease 2019: A Prospective Open-Label Controlled Trial

Xiaowei Gong et al.

Summary: The study conducted a trial to assess the efficacy of Lianhuaqingwen capsules in preventing COVID-19 after close contact with infected individuals, and found that the treatment group had a significantly lower rate of positive nucleic acid tests compared to the control group, indicating that the capsules can effectively prevent the progression of COVID-19.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Add to Collection

Article Plant Sciences

Positive effects of Lianhuaqingwen granules in COVID-19 patients: A retrospective study of 248 cases

Pan Shen et al.

Summary: A retrospective study of 248 patients with moderate COVID-19 found that Lianhuaqingwen significantly improved laboratory results, suggesting its potential as an effective adjunct to standard treatment for COVID-19 patients.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Add to Collection

Review Medicine, General & Internal

Traditional Chinese medicine as an adjunctive therapy for mild and common COVID-19 A systematic review and network meta-analysis

Xiaozheng Wu et al.

Summary: The study evaluated the efficacy and safety of traditional Chinese medicine (TCM) assisted in conventional treatment for mild and common COVID-19 patients. Results showed that TCM can improve the clinical effective rate and main symptoms, with specific TCM remedies like Toujie Quwen, Shufeng Jiedu, and Lianhua Qingwen showing the best performance. In terms of safety, Shufeng Jiedu and Lianhua Qingwen had advantages over conventional treatment.

MEDICINE (2021)

Add to Collection

Review Integrative & Complementary Medicine

Efficacy and safety of herbal medicine (Lianhuaqingwen) for treating COVID-19: A systematic review and meta-analysis

Ming Liu et al.

Summary: The study found that Lianhuaqingwen (LH) combined with conventional treatment has certain efficacy for patients with COVID-19, leading to higher treatment effectiveness and CT recovery rate, and lower incidence of diarrhea, but an increased risk of abnormal liver function.

INTEGRATIVE MEDICINE RESEARCH (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule

Xiao-fang Lan et al.

Summary: This study focused on the herbal component Gancao in LianhuaQingwen capsule, which plays a key role in treating COVID-19. Metabolites of Gancao were found to have an impact on kidney function, highlighting the importance of understanding the therapeutic benefits and safe usage conditions of LianhuaQingwen.

ACTA PHARMACOLOGICA SINICA (2021)

Add to Collection

Review Integrative & Complementary Medicine

Therapeutic effects and safety of oral Chinese patent medicine for COVID-19: A rapid systematic review and meta-analysis of randomized controlled trials

Shi-Bing Liang et al.

Summary: The study found that oral Chinese patent medicine combined with conventional western therapy can improve the cure rate and reduce the aggravation rate of COVID-19 patients, as well as shorten the duration of fever, cough, and fatigue, and improve the improvement and recovery rate of chest CT manifestations.

COMPLEMENTARY THERAPIES IN MEDICINE (2021)

Add to Collection

Review Medicine, Research & Experimental

Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19) treatment: Advances and prospects

Liu-Cheng Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Pharmacology & Pharmacy

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

Li Runfeng et al.

PHARMACOLOGICAL RESEARCH (2020)

Add to Collection

Letter Chemistry, Medicinal

Traditional and complementary medicine during COVID-19 pandemic

Shuvadeep Ganguly et al.

PHYTOTHERAPY RESEARCH (2020)

Add to Collection

Letter Chemistry, Medicinal

Molecular and functional resemblance of dexamethasone and quercetin: A paradigm worth exploring in dexamethasone-nonresponsive COVID-19 patients

Anil Pawar et al.

PHYTOTHERAPY RESEARCH (2020)

Add to Collection

Article Cell Biology

Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19

Qi-Dong Xia et al.

CELL PROLIFERATION (2020)

Add to Collection

© Peeref 2019-2024. All rights reserved.