4.7 Article

Icariside II induces ferroptosis in renal cell carcinoma cells by regulating the miR-324-3p/GPX4 axis

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

p53: A double-edged sword in tumor ferroptosis

Haixia Ji et al.

Summary: This review discusses the role of the p53 gene in regulating ferroptosis, primarily through influencing metabolic networks and signaling pathways that affect tumor cell sensitivity to ferroptosis. This has important implications for further understanding the role of p53 in tumor ferroptosis and developing new strategies for cancer treatment.

PHARMACOLOGICAL RESEARCH (2022)

Article Pharmacology & Pharmacy

Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis

Zi-Xuan Wang et al.

Summary: The study demonstrated that quercetin induces ferroptosis and apoptosis by modulating lysosome function and iron metabolism, suggesting its potential as an anti-cancer agent.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer

Yifeng Hou et al.

Summary: Metformin induces ferroptosis in breast cancer cells by upregulating miR-324-3p, leading to decreased cancer cell viability. The drug promotes ferroptosis by targeting the miR-324-3p/GPX4 axis, suggesting its potential as an anti-cancer agent.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

Article Biochemistry & Molecular Biology

miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549

Shi-hua Deng et al.

Summary: The study revealed that miR-324-3p reversed cisplatin resistance in A549/DDP cells by targeting the GPX4 gene, while also enhancing sensitivity to cisplatin-induced ferroptosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells

Jiangwei Ni et al.

Summary: This study explored the role of GPX4 and mTOR in regulating the response of lung cancer cells to Lapatinib. The upregulation of GPX4 in Lap resistant NSCLC cells was found to be due to enhanced activation of mTORC1. Inhibition of mTORC1 led to downregulation of GPX4, which promoted Lap induced ferroptosis. These findings suggest that targeting GPX4 might enhance the antitumor effects of Lap.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

miR-190a-5p regulates cardiomyocytes response to ferroptosis via directly targeting GLS2

Xiaodao Zhou et al.

Summary: miR-190a-5p negatively regulates ferroptosis in rat cardiomyocytes by targeting GLS2, leading to decreased ROS, MDA, and Fe2+ accumulation. This suggests that miR-190a-5p may serve as a potential therapeutic target for myocardial infarction.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis

Rong Fan et al.

Summary: Pyroptosis and ferroptosis play crucial roles in acute pancreatitis, and Wedelolactone mitigates AP and associated lung injury through GPX4 mediated suppression of pyroptosis and ferroptosis.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Oncology

Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

Fengzhi Li et al.

Summary: Renal cell carcinoma (RCC) is on the rise globally with a challenging therapy-resistance due to multiple genetic and epigenetic alterations. Various proteins like survivin, HIF, NRF2, MDM2, and KRAS are believed to be potential therapeutic biomarkers and targets for treatment resistance.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Cell & Tissue Engineering

MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

Haiwei Ni et al.

Summary: The study revealed that miR-375 can reduce the stemness of gastric cancer cells by targeting SLC7A11 and triggering ferroptosis. The miR-375/SLC7A11 regulatory axis may serve as a potential therapeutic target to attenuate the stemness of gastric cancer cells.

STEM CELL RESEARCH & THERAPY (2021)

Review Medicine, Research & Experimental

The role of necroptosis in disease and treatment

Xiaoxiao Liu et al.

Summary: Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis, is triggered by a series of death receptors, involving key downstream mediators and cell membrane integrity destruction. Research in the past decade has shown that necroptosis is widely involved in life processes. Exploring the therapeutic prospects of necroptosis regulators is important for disease treatment.

MEDCOMM (2021)

Article Cell Biology

miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury

Chenguang Ding et al.

CELL DEATH & DISEASE (2020)

Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

Tobias M. Seibt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Review Biochemistry & Molecular Biology

Choosing the right cell line for renal cell cancer research

Klaudia K. Brodaczewska et al.

MOLECULAR CANCER (2016)

Review Cell Biology

Ferrootosis: Death by Lipid Peroxidation

Wan Seok Yang et al.

TRENDS IN CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Integrative & Complementary Medicine

The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro

F Xie et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2005)