Journal
PHYTOCHEMISTRY LETTERS
Volume 50, Issue -, Pages 141-146Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2022.06.007
Keywords
Euphorbiaceae; Euphorbia peplus; Jatrophane diterpenoid; Autophagic flux
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Funding
- Natural Science Foundation of Yunnan Province [202101AS070139, 202201AW070010, 202001AT070107]
- Science and Technology Program of Guizhou Province [gzwkj2022-222]
- Guizhou Provincial Science and Technology Project [ZK [2022] 393]
- State Key Laboratory of Phytochemistry and Plant Resources in West China [P2020-KF06]
- Yunnan Key Research and Development Program [202003AD150012]
- Central Asian Center of Drug Discovery and Development Center of Chinese Academy of Sciences [CAM202103]
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Three new jatrophane diterpenoids, named euphpepluones P-R (1-3), were isolated from the whole plant Euphorbia peplus. Compounds 2 and 6 showed significant inhibition of autophagic flux, indicating potential bioactivity in this aspect.
Three undescribed jatrophane diterpenoids, named euphpepluones P-R (1-3), were isolated from the whole plant Euphorbia peplus. The structures of these compounds were elucidated by spectroscopic methods. The absolute configuration of 1 was further assigned by X-ray crystallographic analysis. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 2 and 6 exhibited significant inhibition of autophagic flux.
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