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GUT (2015)
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Jacques Ferlay et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
Thymoquinone Restores Radiation-Induced TGF-β Expression and Abrogates EMT in Chemoradiotherapy of Breast Cancer Cells
Shashi Rajput et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2015)
Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway
Jing Yang et al.
TUMOR BIOLOGY (2015)
The Radio-protective effects of Caffeic Acid Phenethyl Ester and Thymoquinone in rats exposed to total head irradiation
Oztekin Cikman et al.
WIENER KLINISCHE WOCHENSCHRIFT (2015)
Protective role of thymoquinone against liver damage induced by tamoxifen in female rats
Ghada M. Suddek
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2014)
Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
Juthika Kundu et al.
FOOD AND CHEMICAL TOXICOLOGY (2014)
Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis
Abdelkader E. Ashour et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2014)
Aqueous Solubility and Degradation Kinetics of the Phytochemical Anticancer Thymoquinone; Probing the Effects of Solvents, pH and Light
Jumah Masoud M. Salmani et al.
MOLECULES (2014)
Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src-mediated phosphorylation of EGF receptor tyrosine kinase
Juthika Kundu et al.
ONCOLOGY REPORTS (2014)
Thymoquinone Induces Cell Death in Human Squamous Carcinoma Cells via Caspase Activation-Dependent Apoptosis and LC3-II Activation-Dependent Autophagy
Shu-Chen Chu et al.
PLOS ONE (2014)
Thymoquinone Induces Apoptosis in Oral Cancer Cells Through P38β Inhibition
Ehab Abdelfadil et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2013)
Effect of thymoquinone on 1,2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis
Hanene Jrah-Harzallah et al.
EUROPEAN JOURNAL OF CANCER (2013)
Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging
Eunhui Seo et al.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)
Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo
Samir Attoub et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2013)
Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration
Siddig Ibrahim Abdelwahab et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2013)
Effects of Selected Bioactive Natural Products on the Vascular Endothelium
Ajaz Ahmad et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2013)
Pronounced transcriptional regulation of apoptotic and TNF-NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells
Cagri Sakalar et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2013)
Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Michaela Lang et al.
MOLECULAR CANCER (2013)
Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro
Landa Zeenelabdin Ali Salim et al.
MOLECULES (2013)
Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway
Lei Peng et al.
ONCOLOGY REPORTS (2013)
Targeted Apoptotic Effects of Thymoquinone and Tamoxifen on XIAP Mediated Akt Regulation in Breast Cancer
Shashi Rajput et al.
PLOS ONE (2013)
Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome
Israr Ahmad et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)
Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma
Subramanian Raghunandhakumar et al.
TOXICOLOGY LETTERS (2013)
The role of thymoquinone as antioxidant protection on oxidative stress induced by imidacloprid in male and female Swiss albino mice
Sinan Ince et al.
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY (2013)
Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo
Xiaofei Lei et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Thymoquinone: Potential cure for inflammatory disorders and cancer
Chern Chiuh Woo et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer
Fadwa Odeh et al.
DRUG DELIVERY (2012)
Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
Kaouther Kolli-Bouhafs et al.
INVESTIGATIONAL NEW DRUGS (2012)
Synthesis of double mesoporous core-shell silica spheres with tunable core porosity and their drug release and cancer cell apoptosis properties
Ahmed Mohamed El-Toni et al.
JOURNAL OF COLLOID AND INTERFACE SCIENCE (2012)
Characterization of Thymoquinone Binding to Human α1-Acid Glycoprotein
Giulio Lupidi et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis
Hanene Jrah Harzallah et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2012)
Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma
Subhasis Das et al.
PLOS ONE (2012)
Thymoquinone attenuates cypermethrin induced oxidative stress in Swiss albino mice
Sinan Ince et al.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2012)
Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP
Arumugam Paramasivam et al.
TOXICOLOGY LETTERS (2012)
A novel approach for stress-induced gastritis based on paradoxical anti-oxidative and anti-inflammatory action of exogenous 8-hydroxydeoxyguanosine
Chan Young Ock et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Evaluation of chemopreventive effects of Thymoquinone on cell surface glycoconjugates and cytokeratin expression during DMBA induced hamster buccal pouch carcinogenesis
G. Rajkamal et al.
BMB Reports (2011)
Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin
Katharina Effenberger-Neidnicht et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)
Elucidation of Molecular Mechanisms Underlying the Protective Effects of Thymoquinone Against Rheumatoid Arthritis
France Vaillancourt et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2011)
Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
El-Shaimaa A. Arafa et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)
PERSPECTIVE The big C - for Chemoprevention
Michael B. Sporn
NATURE (2011)
Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden
L. Connelly et al.
ONCOGENE (2011)
Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats
Mehmet Kanter
TOXICOLOGY AND INDUSTRIAL HEALTH (2011)
Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer
Hareesh B. Nair et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide
F. Q. Alenzi et al.
BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2010)
Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
Feng Li et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species
Padma Sandeep Koka et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2010)
Effects of thymoquinone on isolated and cellular proteasomes
Valentina Cecarini et al.
FEBS JOURNAL (2010)
Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
Maznah Ismail et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Jacques Ferlay et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo
Syed H. Jafri et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2010)
Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
Sanjeev Banerjee et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2010)
Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin
G. Lupidi et al.
PHYTOMEDICINE (2010)
Impact of protein binding on thymoquinone's analytical detection
N El-Najjar et al.
PLANTA MEDICA (2010)
Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
Mohamed M. Sayed-Ahmed et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)
Cancer Prevention With Natural Compounds
Norleena P. Collett et al.
SEMINARS IN ONCOLOGY (2010)
Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells
Andre Wirries et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2010)
Is thymoquinone an antioxidant?
Katrin Staniek et al.
BMC Pharmacology & Toxicology (2010)
被撤回的出版物: Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer (Retracted article. See vol. 78, pg. 5468, 2018)
Sanjeev Banerjee et al.
CANCER RESEARCH (2009)
Cell cycle kinases as therapeutic targets for cancer
Silvia Lapenna et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Thymoquinone Supplementation Induces Quinone Reductase and Glutathione Transferase in Mice Liver: Possible Role in Protection against Chemical Carcinogenesis and Toxicity
Mahmoud N. Nagi et al.
PHYTOTHERAPY RESEARCH (2009)
Effects of Nigella sativa Oil and Thymoquinone on Oxidative Stress and Neuropathy in Streptozotocin-Induced Diabetic Rats
Nadia M. Hamdy et al.
PHARMACOLOGY (2009)
Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
Navdeep Chehl et al.
HPB (2009)
Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
Hala Gali-Muhtasib et al.
CANCER RESEARCH (2008)
Infectious disease complications of combat-related injuries
Clinton K. Murray
CRITICAL CARE MEDICINE (2008)
Antioxidant activities of Toona sinensis leaves extracts using different antioxidant models
You-Cheng Hseu et al.
FOOD AND CHEMICAL TOXICOLOGY (2008)
Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome
Ahmad Najmi
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES (2008)
Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
Tingfang Yi et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression
S. Peter Bak et al.
MOLECULAR IMMUNOLOGY (2008)
Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
Hala Gali-Muhtasib et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)
Androgen receptor- and E2F-1-targeted thymoquinone therapy for hormone-refractory prostate cancer
Ahmed O. Kaseb et al.
CANCER RESEARCH (2007)
Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells
Martin Roepke et al.
CANCER BIOLOGY & THERAPY (2007)
Inflammation, a key event in cancer development
HT Lu et al.
MOLECULAR CANCER RESEARCH (2006)
The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma:: an animal model
MA Abd El-Aziz et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2005)
Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
MA El-Mahdy et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
HU Gali-Muhtasib et al.
ANTI-CANCER DRUGS (2004)
Thymoquinone is a potent superoxide anion scavenger
OA Badary et al.
DRUG AND CHEMICAL TOXICOLOGY (2003)
Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis
EI Salim et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2003)
Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action
MA Mansour et al.
CELL BIOCHEMISTRY AND FUNCTION (2002)
The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats
OA Badary et al.
TOXICOLOGY (2000)
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