Journal
PHYTOCHEMISTRY
Volume 200, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113247
Keywords
Acanthopanax koreanum; Araliaceae; Acanthoic acid; Pharmacological activities; Molecular mechanism; Structural modification
Categories
Funding
- National Natural Science Foundation of China [81973555]
- Department of Science and Technology of Jilin Province [20190304084YY, YDZJ202101ZYTS106]
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Acanthoic acid (AA), isolated from the root bark of Acanthopanax koreanum Nakai, exhibits a wide range of pharmacological activities and targets multiple signaling pathways. Studies have also focused on structural modifications of AA to enhance its pharmacological effects.
Acanthoic acid (AA) is a pimaradiene diterpene isolated from the root bark of Acanthopanax koreanum Nakai (Araliaceae) with a wide range of pharmacological activities, including anti-cancer, anti-inflammatory, antidiabetes, liver protection, gastrointestinal protection, and cardiovascular protection. In addition, AA promotes its pharmacological effects by targeting liver X receptors (LXRs), nuclear factor-kappa B (NF-kappa B), Toll-Like Receptor 4 (TLR4) and IL-1 receptor-associated kinase (IRAK) signaling pathways, or AMP-activated protein kinase (AMPK) signaling pathway, etc. Also, some studies focus on the structural modification of AA to improve its pharmacological activities. The review summarizes the pharmacological activities, molecular mechanism, and the structural modification of AA, which might supply information for the development of AA in the future.
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