Journal
PHYTOCHEMISTRY
Volume 199, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113199
Keywords
Euphorbia neriifolia; Euphorbiaceae; Neritriterpenols; Euphanes; Tirucallane; Anti-inflammation; Anti-proliferation
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Funding
- Ministry of Science and Technology, Republic of China [MOST-108-2320-B-038-030, MOST-107-2320-B077-003-MY3]
- Taipei Medical University [108-TMU-TMUH-05]
- Taipei Medical University Hospital [108-TMU-TMUH-05]
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Euphorbia neriifolia L. is a widely distributed plant with various medicinal properties. This study isolated 11 triterpenes from the plant and determined their structures. Additionally, the anti-inflammatory and antiproliferative effects of these compounds were evaluated, revealing a potential structure-activity relationship.
Euphorbia neriifolia L. is widely distributed in India, Thailand, and China and has been used to treat diseases such as rotten sores and asthma as well as for its antidiabetic and anticancer effects. In this study, seven undescribed triterpenes, including six euphanes, neritriterpenols A-B and D-G, and a tirucallane, neritriterpenol C, together with four known triterpenes, were isolated from ethanolic extracts of E. neriifolia stems. Their structures with absolute configurations were determined through detailed spectroscopic data, including 1D and 2D NMR data analyses, single-crystal X-ray diffraction analysis, ECD spectra, and DP4+ NMR data calculations as well as Mo2(OAc)4-induced ECD analysis. Furthermore, preliminarily evaluation of the anti-inflammatory and antiproliferative effects of the isolated triterpenes leads to the structure-activity relationship (SAR) studies implying that the unsaturated functional group at the end of the C17 side chain on euphane-type triterpenes may be correlated with the increase of anti-inflammatory and anti-proliferative activities.
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