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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Ricki J. Colman et al.
NATURE COMMUNICATIONS (2014)
Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway
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CELL REPORTS (2014)
The Caenorhabditis elegans Myc-Mondo/Mad Complexes Integrate Diverse Longevity Signals
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PLOS GENETICS (2014)
Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster
Nazif Alic et al.
PLOS GENETICS (2014)
A C-terminal truncated mutation of spr-3 gene extends lifespan in Caenorhabditis elegans
Ping Yang et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2013)
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
Joris Deelen et al.
AGE (2013)
Genome Instability and Aging
Jan Vijg et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)
Aging, Cellular Senescence, and Cancer
Judith Campisi
ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)
Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts
Gustavo Barja
ANTIOXIDANTS & REDOX SIGNALING (2013)
Sulforaphane Represses Matrix-Degrading Proteases and Protects Cartilage From Destruction In Vitro and In Vivo
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ARTHRITIS AND RHEUMATISM (2013)
Transcriptional Regulation and Its Misregulation in Disease
Tong Ihn Lee et al.
CELL (2013)
PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity
Ronald G. Tepper et al.
CELL (2013)
Targeting transcription factors: promising new strategies for cancer therapy
Jennifer E. Yeh et al.
CURRENT OPINION IN ONCOLOGY (2013)
Chemical regulation of mid- and late-life longevities in Drosophila
Philip McDonald et al.
EXPERIMENTAL GERONTOLOGY (2013)
Reactive oxygen species and the free radical theory of aging
Stefan I. Liochev
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Longevity in the red flour beetle Tribolium castaneum is enhanced by broccoli and depends on nrf-2, jnk-1 and foxo-1 homologous genes
Stefanie Gruenwald et al.
GENES AND NUTRITION (2013)
Mutations in the Genes Encoding the Transcription Factors Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha in Maturity-Onset Diabetes of the Young and Hyperinsulinemic Hypoglycemia
Kevin Colclough et al.
HUMAN MUTATION (2013)
Insulin Signaling in Type 2 Diabetes EXPERIMENTAL AND MODELING ANALYSES REVEAL MECHANISMS OF INSULIN RESISTANCE IN HUMAN ADIPOCYTES
Cecilia Brannmark et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer
Rene Jackstadt et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
The Intertwined Roles of Transcription and Repair Proteins
Yick W. Fong et al.
MOLECULAR CELL (2013)
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses
Bryan D. Bell et al.
NATURE IMMUNOLOGY (2013)
MECHANISMS OF DISEASE JAKs and STATs in Immunity, Immunodeficiency, and Cancer
John J. O'Shea et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation
Markus Christmann et al.
NUCLEIC ACIDS RESEARCH (2013)
Senescence and aging: the critical roles of p53
A. Rufini et al.
ONCOGENE (2013)
Myc-Dependent Genome Instability and Lifespan in Drosophila
Christina Greer et al.
PLOS ONE (2013)
Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Yong S. Chang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
LongevityMap: a database of human genetic variants associated with longevity
Arie Budovsky et al.
TRENDS IN GENETICS (2013)
Regulation of nuclear factor-κB in autoimmunity
Shao-Cong Sun et al.
TRENDS IN IMMUNOLOGY (2013)
Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation
Hiroki Kabata et al.
NATURE COMMUNICATIONS (2013)
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
Louis R. Lapierre et al.
NATURE COMMUNICATIONS (2013)
A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans
Masaharu Uno et al.
CELL REPORTS (2013)
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
Emilia Kansanen et al.
REDOX BIOLOGY (2013)
The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking
Sung Y. Kim et al.
AGING CELL (2012)
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
Jose A. Martina et al.
AUTOPHAGY (2012)
HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity
Wei-Chung Chiang et al.
CELL (2012)
MAD1 and its life as a MYC antagonist: An update
Bernhard Luescher
EUROPEAN JOURNAL OF CELL BIOLOGY (2012)
In vivo biological activity of rocket extracts (Eruca vesicaria subsp sativa (Miller) Thell) and sulforaphane
M. Villatoro-Pulido et al.
FOOD AND CHEMICAL TOXICOLOGY (2012)
The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism
Xiwen Xiong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms
Michael Plank et al.
MOLECULAR BIOSYSTEMS (2012)
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Julie A. Mattison et al.
NATURE (2012)
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy
Kristan E. van der Vos et al.
NATURE CELL BIOLOGY (2012)
AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Genetic Signatures of Exceptional Longevity in Humans
Paola Sebastiani et al.
PLOS ONE (2012)
The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegans
Xiao Xu et al.
PLOS GENETICS (2012)
The STAT5b pathway defect and autoimmunity
Takahiro Kanai et al.
FRONTIERS IN IMMUNOLOGY (2012)
Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors
Peter C. Hollenhorst et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
Regulation of FoxO transcription factors by acetylation and protein-protein interactions
Hiroaki Daitoku et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
Regulation of FOXO protein stability via ubiquitination and proteasome degradation
Haojie Huang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
Guri Tzivion et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
Akt, FoxO and regulation of apoptosis
Xinbo Zhang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation
Gerasimos P. Sykiotis et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2011)
Extending life span by increasing oxidative stress
Michael Ristow et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
JNK regulates FoxO-dependent autophagy in neurons
Ping Xu et al.
GENES & DEVELOPMENT (2011)
Pioneer transcription factors: establishing competence for gene expression
Kenneth S. Zaret et al.
GENES & DEVELOPMENT (2011)
Signal transduction by reactive oxygen species
Toren Finkel
JOURNAL OF CELL BIOLOGY (2011)
Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse
Hamid Reza Rezvani et al.
JOURNAL OF CELL SCIENCE (2011)
The FOXO3A rs2802292 G-Allele Associates with Improved Peripheral and Hepatic Insulin Sensitivity and Increased Skeletal Muscle-FOXO3A mRNA Expression in Twins
Karina Banasik et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
Daniel W. Neef et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan et al.
SCIENCE (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
The Homeobox Protein CEH-23 Mediates Prolonged Longevity in Response to Impaired Mitochondrial Electron Transport Chain in C. elegans
Ludivine Walter et al.
PLOS BIOLOGY (2011)
Transcription Factors in Heart: Promising Therapeutic Targets in Cardiac Hypertrophy
Shrey Kohli et al.
CURRENT CARDIOLOGY REVIEWS (2011)
Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice
Yuliya V. Dubrovsky et al.
AGING-US (2010)
Transcriptome analysis and tumor suppressor requirements of STAT5-induced senescence
Frederick A. Mallette et al.
AGING, CANCER, AND AGE-RELATED DISEASES: COMMON MECHANISM? (2010)
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging
Fabio Demontis et al.
CELL (2010)
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
Nirmala Hariharan et al.
CIRCULATION RESEARCH (2010)
A role for p53 in mitochondrial stress response control of longevity in C. elegans
Alessandro Torgovnick et al.
EXPERIMENTAL GERONTOLOGY (2010)
Nonhistone protein acetylation as cancer therapy targets
Brahma N. Singh et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2010)
Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity
Kaitlyn N. Lewis et al.
INTEGRATIVE AND COMPARATIVE BIOLOGY (2010)
Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts
Suzanne Kapeta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved in Cell Senescence
You-Mie Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
Amar J. Majmundar et al.
MOLECULAR CELL (2010)
Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
Brian Onken et al.
PLOS ONE (2010)
Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies
Jun Hee Lee et al.
SCIENCE (2010)
Extending Healthy Life Span-From Yeast to Humans
Luigi Fontana et al.
SCIENCE (2010)
Identification of a Primary Target of Thalidomide Teratogenicity
Takumi Ito et al.
SCIENCE (2010)
ETS-4 Is a Transcriptional Regulator of Life Span in Caenorhabditis elegans
Bargavi Thyagarajan et al.
PLOS GENETICS (2010)
The ageing epigenome: Damaged beyond repair?
David A. Sinclair et al.
AGEING RESEARCH REVIEWS (2009)
Longevity regulation in flies: A role for p53
Lawrence A. Donehower
AGING-US (2009)
AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity
Eric L. Greer et al.
INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE (2009)
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
Evan T. Powers et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Theoretical estimation of maximum human lifespan
Byung Mook Weon et al.
BIOGERONTOLOGY (2009)
Autophagy Is Required to Maintain Muscle Mass
Eva Masiero et al.
CELL METABOLISM (2009)
The role of FOXO in the regulation of metabolism
Danielle N. Gross et al.
CURRENT DIABETES REPORTS (2009)
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations
Yang Li et al.
HUMAN MOLECULAR GENETICS (2009)
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Ethan J. Anderson et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands
William H. Bisson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C-elegans
Sakiko Honjoh et al.
NATURE (2009)
The evolution of Fox genes and their role in development and disease
Sridhar Hannenhalli et al.
NATURE REVIEWS GENETICS (2009)
Metabolism control by the circadian clock and vice versa
Kristin Eckel-Mahan et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans
Yi Zhang et al.
PLOS ONE (2009)
Association of FOXO3A variation with human longevity confirmed in German centenarians
Friederike Flachsbart et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman et al.
SCIENCE (2009)
Caloric Restriction and Aging: Studies in Mice and Monkeys
Rozalyn M. Anderson et al.
TOXICOLOGIC PATHOLOGY (2009)
HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans
Di Chen et al.
PLOS GENETICS (2009)
Awakening guardian angels: drugging the p53 pathway
Christopher J. Brown et al.
NATURE REVIEWS CANCER (2009)
Genes encoding longevity: from model organisms to humans
Maris Kuningas et al.
AGING CELL (2008)
Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster:: not required, but its activity modulates the response
Maria E. Giannakou et al.
AGING CELL (2008)
Valproic acid extends Caenorhabditis elegans lifespan
Kimberley Evason et al.
AGING CELL (2008)
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
Anne Simonsen et al.
AUTOPHAGY (2008)
Downstream of Akt: FoxO3 and m TOR in the regulation ofautophagy in skeltal muscle
Cristina Mammucari et al.
AUTOPHAGY (2008)
Longevity pathways converge on autophagy genes to regulate He span in Caenorhabditis elegans
Marton L. Toth et al.
AUTOPHAGY (2008)
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C-elegans
Yelena V. Budovskaya et al.
CELL (2008)
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
Jennifer M. A. Tullet et al.
CELL (2008)
The common germline Arg72Pro polymorphism of p53 and increased longevity in humans
Stig E. Bojesen et al.
CELL CYCLE (2008)
Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling
Gaelle Laurent et al.
CELL METABOLISM (2008)
The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging
Karyn L. Sheaffer et al.
CURRENT BIOLOGY (2008)
Age-dependent impairment of HIF-1α expression in diabetic mice:: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
Lixin Liu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2008)
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
Fiona Pickford et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
NF-κB in inflammatory bowel disease
I. Atreya et al.
JOURNAL OF INTERNAL MEDICINE (2008)
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet
Yuji Tanaka et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt
Kazuyuki Yamagata et al.
MOLECULAR CELL (2008)
Forkhead transcription factors and ageing
L. Partridge et al.
ONCOGENE (2008)
JNK signaling in apoptosis
D. N. Dhanasekaran et al.
ONCOGENE (2008)
FOXO3A genotype is strongly associated with human longevity
Bradley J. Wilicox et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
FoxO3 controls autophagy in skeletal muscle in vivo
Cristina Mammucari et al.
CELL METABOLISM (2007)
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
Andrew V. Samuelson et al.
GENES & DEVELOPMENT (2007)
Circadian clocks: regulators of endocrine and metabolic rhythms
Michael Hastings et al.
JOURNAL OF ENDOCRINOLOGY (2007)
A C-elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration
Christopher L. Pickett et al.
DEVELOPMENTAL BIOLOGY (2007)
Ageing or cancer: A review On the role of caretakers and gatekeepers
D. van Heemst et al.
EUROPEAN JOURNAL OF CANCER (2007)
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
Tim J. Schulz et al.
CELL METABOLISM (2007)
Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity
Oge Arum et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2007)
The transcription factors Stat5a/b are not required for islet development but modulate pancreatic β-cell physiology upon aging
Ji-Yeon Lee et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan
Yongsoon Kim et al.
AGING CELL (2007)
Cellular senescence in cancer and aging
Manuel Collado et al.
CELL (2007)
The multifunctional nucleolus
Francois-Michel Boisvert et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Two neurons mediate diet-restriction-induced longevity in C-elegans
Nicholas A. Bishop et al.
NATURE (2007)
PHA-4/Foxa mediates diet-restriction-induced longevity of C-elegans
Siler H. Panowski et al.
NATURE (2007)
A role of the circadian system and circadian proteins in aging
Roman V. Kondratov
AGEING RESEARCH REVIEWS (2007)
Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents
H-S Lin et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Aging, adiposity, and calorie restriction
Luigi Fontana et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)
Downregulation of transcription factor, Sp1, during cellular senescence
Ji-Eun Oh et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis
Alessandro Pandini et al.
BIOCHEMISTRY (2007)
Sp1 Is Essential for p16INK4a Expression in Human Diploid Fibroblasts during Senescence
Junfeng Wu et al.
PLOS ONE (2007)
Expression of Nrf2 in neurodegenerative diseases
Chenere P. Ramsey et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
Stressing the role of FoxO proteins in lifespan and disease
Armando van der Horst et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
The Foxa family of transcription factors in development and metabolism
J. R. Friedman et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock
Roman V. Kondratov et al.
GENES & DEVELOPMENT (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara et al.
NATURE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA
MY Ying et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Transcriptional regulation of metabolism
B Desvergne et al.
PHYSIOLOGICAL REVIEWS (2006)
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16INK4a
I Guney et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Critical nodes in signalling pathways: insights into insulin action
CM Taniguchi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1)
Dale G. Nagle et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
TRANSFAC (R) and its module TRANSCompel (R): transcriptional gene regulation in eukaryotes
V. Matys et al.
NUCLEIC ACIDS RESEARCH (2006)
GATA transcription factors and hematological diseases
Hideo Harigae
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2006)
The quest for genetic determinants of human longevity: challenges and insights
Kaare Christensen et al.
NATURE REVIEWS GENETICS (2006)
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
JH Bauer et al.
CURRENT BIOLOGY (2005)
Identification of potential caloric restriction mimetics by microarray profiling
JM Dhahbi et al.
PHYSIOLOGICAL GENOMICS (2005)
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
M Columbaro et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
H Iwasaki et al.
BLOOD (2005)
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster
LWM Loo et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems
MP Mattson et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2005)
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex
VY Gorbacheva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Zinc fingers as protein recognition motifs: Structural basis for the GATA-1/Friend of GATA interaction
CK Liew et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Variation in the human TP53 gene affects old age survival and cancer mortality
D van Heemst et al.
EXPERIMENTAL GERONTOLOGY (2005)
Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts
HK Kim et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2005)
Trichostatin a extends the lifespan of Drosophila melanogaster by elevating hsp22 expression
D Tao et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2004)
GATA transcription factors in the developing and adult heart
S Pikkarainen et al.
CARDIOVASCULAR RESEARCH (2004)
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
MAG Essers et al.
EMBO JOURNAL (2004)
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
J Brugarolas et al.
GENES & DEVELOPMENT (2004)
AP-1 subunits: quarrel and harmony among siblings
J Hess et al.
JOURNAL OF CELL SCIENCE (2004)
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
DS Hwangbo et al.
NATURE (2004)
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
RD Rudic et al.
PLOS BIOLOGY (2004)
The paradox of the insulin/IGF-1 signaling pathway in longevity
M Rincon et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways
T Kojima et al.
EXPERIMENTAL GERONTOLOGY (2004)
Insulin/IGF-I-signaling pathway:: an evolutionarily conserved mechanism of longevity from yeast to humans
M Barbieri et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure-with advanced age
JJ Jacoby et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Regulating histone acetyltransferases and deacetylases
G Legube et al.
EMBO REPORTS (2003)
Autophagy genes are essential for dauer development and life-span extension in C-elegans
A Meléndez et al.
SCIENCE (2003)
Werner syndrome protein limits MYC-induced cellular senescence
C Grandori et al.
GENES & DEVELOPMENT (2003)
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
AL Hsu et al.
SCIENCE (2003)
Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
A Krones-Herzig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Growth hormone stimulates proliferation of old-aged regenerating liver through Forkhead Box m1b
K Krupczak-Hollis et al.
HEPATOLOGY (2003)
Circadian rhythms, oxidative stress, and antioxidative defense mechanisms
R Hardeland et al.
CHRONOBIOLOGY INTERNATIONAL (2003)
Sp1-and Kruppel-like transcription factors
J Kaczynski et al.
GENOME BIOLOGY (2003)
Zinc fingers - Folds for many occasions
JM Matthews et al.
IUBMB LIFE (2002)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
XS Gao et al.
NATURE CELL BIOLOGY (2002)
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