Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 197, Issue 12, Pages 1277-1283Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426507.2022.2097232
Keywords
Methyl 2-fluoro-3-hydroxypropanoate; Claisen salt; water; methyl 3-chloro-2-fluoropropanoate; methyl 2-fluoroacrylate
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Funding
- National Natural Science Foundation of China [81502022, 21702153]
- Natural Science Foundation of Xiaogan, Hubei Province, China [XGKJ2019010046]
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The synthesis of MFHP from Claisen salts and formaldehyde in water is developed, providing a novel strategy to overcome the shortcomings of MFA and improve storage life and cost efficiency.
Methyl 2-fluoro-3-hydroxypropanoate (MFHP) and its derivative methyl 3-chloro-2-fluoropropanoate (MCFP) are easily converted into methyl 2-fluoroacrylate (MFA). A roundabout strategy was put forward based on MFHP to overcome the shortcomings of MFA to extend its storage life and reduce its cost of shipment and storage. In our work, a novel and facile method for the synthesis of MFHP was developed based on Claisen salts and formaldehyde in water as followed: 37% formaldehyde aqueous (9.0 equiv.) was dropped into the aqueous of Claisen salt (1.0 equiv.) and NaHCO3 (1.0 equiv.) at room temperature for 2-3 h to obtain MFHP in yield of 81.3%.
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