Journal
PHARMACOLOGY & THERAPEUTICS
Volume 236, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2022.108112
Keywords
UGRP1; SCGB1A1; CCSP; CC10; SCGB3A1; Anti-inflammatory; Growth factor; Anti-fibrotic; Anti-cancer; Lung diseases
Categories
Funding
- National Cancer Institute Intramural Research Program [ZIA BC 010449]
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SCGB3A2 is a secreted small protein predominantly expressed in airway epithelial Club cells. It possesses anti-inflammatory, growth factor, anti-fibrotic, and anti-cancer activities that influence various lung diseases.
Secretoglobin (SCGB) 3A2 was first identified in 2001 as a protein exhibiting similarities in amino acid sequence and gene structure to SCGB1A1, a multi-functional cytokine-like molecule highly expressed in airway epithelial Club cells that was the first identified and extensively studied member of the SCGB gene superfamily. SCGB3A2 is a small secretory protein of similar to 10 kDa that forms a dimer and a tetramer. SCGB3A2 is predominantly expressed in airway epithelial Club cells, and has anti-inflammatory, growth factor, anti-fibrotic, and anti-cancer activities that influence various lung diseases. This review summarizes the current understanding of SCGB3A2 biological functions and its role in human diseases with emphasis on its mechanisms of actions and signaling pathway. (C) 2022 Published by Elsevier Inc.
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