4.7 Article

Targeting the WASF3 complex to suppress metastasis

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

In SilicoOptimized Stapled Peptides Targeting WASF3 in BreastCancer

Ameya J. Limaye et al.

Summary: WASF3 plays a crucial role in actin cytoskeletal dynamics and is directly associated with breast cancer metastasis and invasion. The development of a second generation WASF3 mimetic peptide, WAHMIS-2, has been shown to effectively disrupt the binding of WASF3 to the WRC, leading to the suppression of breast cancer cell motility and invasion.

ACS MEDICINAL CHEMISTRY LETTERS (2022)

Article Pathology

Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer

Haiyan Qin et al.

AMERICAN JOURNAL OF PATHOLOGY (2019)

Article Oncology

Are 90% of deaths from cancer caused by metastases?

Hanna Dillekas et al.

CANCER MEDICINE (2019)

Article Medicine, Research & Experimental

Overexpression of WAVE3 promotes tumor invasiveness and confers an unfavorable prognosis in human hepatocellular carcinoma

Yingjie Ji et al.

BIOMEDICINE & PHARMACOTHERAPY (2015)

Article Biochemistry & Molecular Biology

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

Baoyu Chen et al.

Article Cell Biology

Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton

Xing Judy Chen et al.

DEVELOPMENTAL CELL (2014)

Review Oncology

Regulatory networks defining EMT during cancer initiation and progression

Bram De Craene et al.

NATURE REVIEWS CANCER (2013)

Review Cell Biology

Pathological roles of invadopodia in cancer invasion and metastasis

Hideki Yamaguchi

EUROPEAN JOURNAL OF CELL BIOLOGY (2012)

Article Oncology

HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions

Pushpankur Ghoshal et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

Review Cell Biology

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

Danielle A. Murphy et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

Article Cell Biology

WASP Family Proteins: Their Evolution and Its Physiological Implications

Douwe M. Veltman et al.

MOLECULAR BIOLOGY OF THE CELL (2010)

Article Multidisciplinary Sciences

Structure and control of the actin regulatory WAVE complex

Zhucheng Chen et al.

NATURE (2010)

Article Oncology

WAVE3 is associated with invasiveness in prostate cancer cells

Herman S. Fernando et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2010)

Article Multidisciplinary Sciences

Free Brick1 Is a Trimeric Precursor in the Assembly of a Functional Wave Complex

Emmanuel Derivery et al.

PLOS ONE (2008)

Article Biochemistry & Molecular Biology

c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration

Khalid Sossey-Alaoui et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Genetics & Heredity

Genetic determinants of cancer metastasis

Don X. Nguyen et al.

NATURE REVIEWS GENETICS (2007)

Article Biochemistry & Molecular Biology

WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase

K Sossey-Alaoui et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Hematology

WAVE/scars in platelets

A Oda et al.

BLOOD (2005)

Letter Cell Biology

Abi1 is essential for the formation and activation of a WAVE2 signalling complex

M Innocenti et al.

NATURE CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation

A Steffen et al.

EMBO JOURNAL (2004)

Review Cell Biology

Regulation of actin dynamics by WASP and WAVE family proteins

TEB Stradal et al.

TRENDS IN CELL BIOLOGY (2004)

Article Multidisciplinary Sciences

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

S Eden et al.

NATURE (2002)