☆ 4.7 Review

The gut-lung axis in severe acute Pancreatitis-associated lung injury: The protection by the gut microbiota through short-chain fatty acids

PHARMACOLOGICAL RESEARCH (2022)

Related references

Note: Only part of the references are listed.
Review Medicine, Research & Experimental

Dual role of microbiota-derived short-chain fatty acids on host and pathogen

Rasoul Mirzaei et al.

Summary: SCFAs play important roles in maintaining colonic health, regulating gene expression and cell differentiation, and anti-inflammatory effects, as well as affecting the virulence factors of bacterial pathogens. Bacteria rely on sensing environmental signals to find preferable niches and reach the infectious state.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection
Review Food Science & Technology

The role of short-chain fatty acids in immunity, inflammation and metabolism

Yao Yao et al.

Summary: Short-chain fatty acids (SCFAs) are important metabolites of gut microbiome and play a vital role in host health. They are key energy sources for colon and ileum cells, regulate intestinal epithelial barrier and defense functions, modulate the function of innate immune cells, regulate the differentiation of T cells and B cells, and also inhibit tumor cell proliferation and promote apoptosis.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Add to Collection
Article Pharmacology & Pharmacy

Butyrate ameliorates skeletal muscle atrophy in diabetic nephropathy by enhancing gut barrier function and FFA2-mediated PI3K/Akt/mTOR signals

Gang Tang et al.

Summary: This study revealed that supplementation with butyrate can improve serum butyrate levels in DN patients and enhance intestinal barrier function in db/db mice, alleviating muscle atrophy. In HG/LPS-exposed C2C12 cells, butyrate activates the FFA2 receptor-mediated PI3K/Akt/mTOR pathway, suppressing oxidative stress and autophagy.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Add to Collection
Review Oncology

Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?

Huiqin Hou et al.

Summary: Colorectal cancer is the third most common cancer worldwide, and its development is closely related to changes in the gut microbiota and metabolites. Short-chain fatty acids play a crucial role in promoting intestinal health, inhibiting tumor development, and enhancing responses to chemotherapy and immunotherapy.

CANCER LETTERS (2022)

Add to Collection
Article Immunology

The effect of short-chain fatty acids on M2 macrophages polarization in vitro and in vivo

Chunrong Huang et al.

Summary: Short-chain fatty acids can inhibit M2 polarization of alveolar macrophages through GPR43 activation and/or HDAC inhibition, and they can also help alleviate airway inflammation in an asthma model.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2022)

Add to Collection
Article Medicine, Research & Experimental

Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway

Liping Liang et al.

Summary: In this study, it was found that butyrate increased mucin production and the proportion of mucin-secreting goblet cells in the colon crypt in a macrophage-dependent manner. Additionally, butyrate facilitated M2 macrophage polarization and enhanced goblet cell function. The adoptive transfer of butyrate-induced M2 macrophages also promoted goblet cell and mucus restoration in ulcerative colitis.

CLINICAL SCIENCE (2022)

Add to Collection
Review Biotechnology & Applied Microbiology

Interplay between Dysbiosis of Gut Microbiome, Lipid Metabolism, and Tumorigenesis: Can Gut Dysbiosis Stand as a Prognostic Marker in Cancer?

Indranil Chattopadhyay et al.

Summary: The gut bacterial community plays a crucial role in the metabolism of bile acids and short-chain fatty acids, and their metabolites have significant effects on host pathophysiology. Understanding the interaction between gut microbiota and bile acid and SCFA metabolism is crucial for studying gastrointestinal cancer development.

DISEASE MARKERS (2022)

Add to Collection
Article Gastroenterology & Hepatology

Gut microbiome and health: mechanistic insights

Willem M. de Vos et al.

Summary: The gut microbiota plays a crucial role in regulating host health and its deviations are linked with various diseases. Understanding the molecular aspects of the gut microbiota's influence on health can lead to the development of novel therapies.

GUT (2022)

Add to Collection
Article Cell Biology

Short-Chain Fatty Acid Decreases the Expression of CEBPB to Inhibit miR-145-Mediated DUSP6 and Thus Further Suppresses Intestinal Inflammation

Qian Liu et al.

Summary: Short-chain fatty acid (SCFA) inhibits DUSP6 by upregulating miR-145 through repression of CEBPB, thus preventing the development of intestinal inflammation both in vitro and in vivo.

INFLAMMATION (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis

Piero Portincasa et al.

Summary: The gut microbiota consists of trillions of commensal microorganisms including bacteria, fungi, and viruses, which coexist in symbiosis with the host and have profound effects on human health. Short chain fatty acids (SCFAs) are the most abundant bacterial metabolites in the human body and play an important role in metabolic, endocrine, and immune functions. Diet can influence the composition and activity of the gut microbiota, as well as SCFAs production and metabolic effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Review Biochemistry & Molecular Biology

The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases?

Binoy Shivanna et al.

Summary: The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor that plays a vital role in the development of liver and regulation of various physiological processes. This review summarizes the mechanistic role(s) and therapeutic potential of AHR in acute lung injury, chronic obstructive pulmonary disease, and bronchopulmonary dysplasia, highlighting its translational potential for managing these lung disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Article Plant Sciences

Yanning Syrup ameliorates the lipopolysaccharide-induced inflammation: Adjusting the gut microbiota, short-chain fatty acids, and the CD4+ T cell balance

Danni Wei et al.

Summary: The study revealed that Yanning Syrup could ameliorate LPS-induced inflammation in rats by modifying gut microbiota, increasing microbiota-derived short-chain fatty acid production, and regulating the balance of Th1/Th2 and Treg/Th17 cells.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Effects of valerate on intestinal barrier function in cultured Caco-2 epithelial cell monolayers

Guanzhen Gao et al.

Summary: The study found that valerate, a SCFAs converted mainly from proteins or amino acids, promotes intestinal barrier function at physiological concentrations, similar to butyrate but with a broader range of effective concentrations. This activity is associated with valerate-induced AMPK activation and tight junctions assembly, highlighting its potential role in intestinal health.

MOLECULAR BIOLOGY REPORTS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Activation of TLR4 induces severe acute pancreatitis-associated spleen injury via ROS-disrupted mitophagy pathway

E. Wen et al.

Summary: This study investigated the mechanism of spleen injury caused by severe acute pancreatitis (SAP) and explored the potential use of tuftsin in treating spleen damage. The researchers found that the up-regulation of Toll-like receptor 4 (TLR4) in the spleen leads to the accumulation of reactive oxygen species (ROS) and mitochondrial dysfunction under SAP conditions. They also discovered that N-acetylcysteine (NAC) treatment or knocking out TLR4 can improve splenic ROS and mitochondrial dysfunction in SAP mice. Furthermore, they verified that spleen injury is caused by splenic ROS affecting the PI3K/p-AKT/mTOR pathway-mediated autophagy. The study also showed that tuftsin supplementation can ameliorate the pathological damage, ROS accumulation, impaired autophagy, inflammation expression, and apoptosis in damaged spleen.

MOLECULAR IMMUNOLOGY (2022)

Add to Collection
Article Pharmacology & Pharmacy

Traditional Patchouli essential oil modulates the host's immune responses and gut microbiota and exhibits potent anti-cancer effects in ApcMin /+mice

Waikit Leong et al.

Summary: Patchouli Essential Oil (PEO) and its derivatives, patchouli alcohol (PA) and pogostone (PO), show potent anti-cancer effects by reducing tumor burden, strengthening the epithelial barrier, modulating macrophage phenotypes, remodeling the inflammatory milieu, and influencing immune cells and gut microbiota. The activation of short-chain fatty acids and their receptors plays a key role in mediating these effects.

PHARMACOLOGICAL RESEARCH (2022)

Add to Collection
Article Agriculture, Dairy & Animal Science

Dietary fibers with different viscosity regulate lipid metabolism via ampk pathway: roles of gut microbiota and short-chain fatty acid

Yu Li et al.

Summary: Dietary fiber plays a crucial role in gastrointestinal health and its effect on goose growth and lipid levels varies with different viscosities. High viscosity fiber has a better lipid-lowering effect, while medium viscosity fiber provides better intestinal mucosal protection.

POULTRY SCIENCE (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis

Ying Lan et al.

Summary: Seabuckthorn polysaccharide (SP) has shown significant amelioration effects on obesity induced by a high-fat diet (HFD) in mice. The effects of SP are mediated through modulation of the gut microbiota and its metabolites, leading to reductions in body weight gain, serum lipid levels, and liver triglyceride levels. SP regulates liver lipid metabolism by influencing the composition of the gut microbiome and increasing the production of short-chain fatty acids (SCFAs). These findings suggest that SP could be a potential nutraceutical for alleviating obesity by targeting the gut-liver axis.

FOOD & FUNCTION (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis

Pei Li et al.

Summary: In this study, live L. acidophilus (La) showed the best therapeutic effect on ulcerative colitis (UC) rats. It achieved this by regulating SCFAs to balance inflammation and improve intestinal barrier function. These findings provide new theoretical basis for the application of L. acidophilus and its interaction with host immunity.

FOOD & FUNCTION (2022)

Add to Collection
Article Nutrition & Dietetics

Weight Loss and Short-Chain Fatty Acids Reduce Systemic Inflammation in Monocytes and Adipose Tissue Macrophages from Obese Subjects

Shaun Eslick et al.

Summary: Weight loss and ex vivo short-chain fatty acid (SCFA) treatments were found to successfully attenuate systemic inflammation in obese individuals. These treatments not only reduced the production of inflammatory cytokines, but also altered the expression of certain genes.

NUTRIENTS (2022)

Add to Collection
Article Biotechnology & Applied Microbiology

Rhubarb Enema Increasing Short-Chain Fatty Acids that Improves the Intestinal Barrier Disruption in CKD May Be Related to the Regulation of Gut Dysbiosis

Chunlan Ji et al.

Summary: Rhubarb enema can improve the intestinal barrier damage in CKD, possibly by regulating the production of short-chain fatty acid-producing gut microbiota.

BIOMED RESEARCH INTERNATIONAL (2022)

Add to Collection
Article Immunology

Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis

Marina Gomes Machado et al.

Summary: In this study, a new mechanism through which acetate enhances the bactericidal activity of alveolar macrophages has been revealed. Acetate triggers a transcriptomic program in macrophages, leading to changes in metabolic process and immune effector outputs, including nitric oxide (NO) production. Acetate also improves the killing activity of macrophages towards Streptococcus pneumoniae in an NO-dependent manner, which involves IL-1 beta production, NLRP3 inflammasome, and activation of HIF-1 alpha.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection
Article Cell Biology

Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook

Saeed Al Mahri et al.

Summary: Fatty acids are important molecules involved in energy production and biological membrane structure. Recent studies have shown that fatty acids can activate receptors on cell surfaces and impact physiological processes. FFARs, activated by fatty acids, play crucial roles in regulating whole-body metabolism. These findings provide new pharmacological targets for the treatment of obesity and type 2 diabetes.

CELLS (2022)

Add to Collection
Article Agriculture, Dairy & Animal Science

Integrity of the Intestinal Barrier: The Involvement of Epithelial Cells and Microbiota-A Mutual Relationship

Malgorzata Gierynska et al.

Summary: This article discusses the importance of the gastrointestinal tract and the key mechanisms of communication between the gut microbiota and epithelial cells in maintaining intestinal homeostasis. The article emphasizes the role of the mucosal barrier and how intestinal epithelial cells maintain barrier integrity through mucus secretion, formation of intercellular junctions, and production of antimicrobial peptides. The article also discusses how imbalances in regulation can lead to barrier damage and dysbiosis, contributing to inflammatory and metabolic diseases.

ANIMALS (2022)

Add to Collection
Review Gastroenterology & Hepatology

Epigenetic regulation by gut microbiota

Vivienne Woo et al.

Summary: The complex relationship between the gastrointestinal tract and microbiota is regulated by epigenetic modifications, including modifications to DNA or histones and regulation of non-coding RNAs. Further research is needed to fully understand the mechanisms of epigenetic regulation.

GUT MICROBES (2022)

Add to Collection
Article Medicine, Research & Experimental

Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models

Ejas Palathingal Bava et al.

Summary: This study evaluated the efficacy of pirfenidone in treating acute pancreatitis. The results showed that pirfenidone can reduce local and systemic injury and inflammation caused by pancreatitis, suggesting its potential therapeutic effects. Pirfenidone acts by decreasing cytokine release and disrupting cellular interactions.

JCI INSIGHT (2022)

Add to Collection
Article Food Science & Technology

Red Fruits Composition and Their Health Benefits-A Review

Fernanda Cosme et al.

Summary: This review aims to summarize recent research on the health benefits of selected red fruits, as well as the relationship between fruit intake and reduced risk of chronic diseases.

FOODS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Gastrointestinal Microbiome and Neurologic Injury

Eric J. Panther et al.

Summary: The communication between the enteric nervous system (ENS) of the gastrointestinal (GI) tract and the central nervous system (CNS) is crucial for maintaining systemic homeostasis. The health of the gut microbiome plays a vital role in regulating the overall function and well-being of the individual, and neurological injuries can modulate the status of the microbiome. Interventions such as probiotics, fecal microbiota transplantation, and oral SCFAs may be beneficial in the recovery from neurological injuries.

BIOMEDICINES (2022)

Add to Collection
Article Biology

Lung Microbiome in Critically Ill Patients

Melanie Fromentin et al.

Summary: The historical hypothesis of sterility of the lungs has been invalidated by studies that prove the existence of diverse bacterial populations in the normal lung, and the association between pulmonary dysbiosis and chronic respiratory diseases. Dysbiosis occurs rapidly during mechanical ventilation, leading to a decline in diversity and the dominance of bacterial pathogens. In acute respiratory distress syndrome, there is an enrichment of intestinal bacteria, but its role in the pathogenesis of ventilator-associated pneumonia and acute respiratory distress syndrome is not fully understood. Further exploration of microbial populations, viruses, and fungi, as well as understanding the host-microbiome interaction, is necessary to fully elucidate the role of the microbiome in acute diseases.

LIFE-BASEL (2022)

Add to Collection
Review Immunology

Macrophages in Transplantation: A Matter of Plasticity, Polarization, and Diversity

Sarah E. Panzer

Summary: Macrophages have gained increasing attention in immunology and transplantation research due to recent advances, which have revealed new populations, expanded traditional phenotypes, and improved our understanding of their development. These findings have significant implications for transplant immunology.

TRANSPLANTATION (2022)

Add to Collection
Review Medicine, Research & Experimental

Advances in research on the effects of platelet activation in acute lung injury (Review)

Yuan Xin et al.

Summary: This review paper reveals the important role of platelets in the pathogenesis of acute lung injury, including the secretion of bioactive mediators, activation-related signaling pathways, and direct contact reactions with neutrophils and endothelial cells.

BIOMEDICAL REPORTS (2022)

Add to Collection
Article Allergy

Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function

Mirelle T. A. Kleuskens et al.

Summary: The study investigated the effects of SCFAs acetate, propionate, and butyrate on the esophageal barrier function in EoE, finding that butyrate and propionate can restore the barrier function of esophageal epithelial cells after inflammatory insult. This suggests that these nutraceuticals may have therapeutic benefits in managing EoE.

ALLERGY (2022)

Add to Collection
Article Microbiology

Short-Chain Fatty Acids Modulate Healthy Gut Microbiota Composition and Functional Potential

Christine Tara Peterson et al.

Summary: This study evaluated the potential of short-chain fatty acids (SCFAs) to modulate the structure and function of the human gut microbiota. Each SCFA displayed unique modulatory potential, altering the fitness of specific bacterial strains through cross-feeding. These findings are important for the identification of prebiotics that can enhance the therapeutic effects of specific SCFAs.

CURRENT MICROBIOLOGY (2022)

Add to Collection
Article Microbiology

Rhubarb Alleviates Acute Lung Injury by Modulating Gut Microbiota Dysbiosis in Mice

Tingyu Tang et al.

Summary: This study found that both patients with acute lung injury (ALI) and mouse models exhibited dysbiosis of gut microbiota, leading to an imbalance of Th17/Treg cells. Treatment with rhubarb promoted the proliferation of beneficial bacteria, increased the concentration of HDAC6, restored the balance of Th17/Treg cells, and protected against ALI.

CURRENT MICROBIOLOGY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Impact of short-chain fatty acid supplementation on gut inflammation and microbiota composition in a murine colitis model

Jae Gon Lee et al.

Summary: Supplementation of SCFAs did not lead to a significant reduction in colon inflammation, but it did increase the expression of regulatory T cells and IL-17-producing T cells, as well as promote both protective and aggressive gut microbiota.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

Add to Collection
Review Nutrition & Dietetics

Novel advances in understanding fatty acid-binding G protein-coupled receptors and their roles in controlling energy balance

Min Tian et al.

Summary: Diabetes, obesity, and other metabolic diseases are recognized as major factors endangering human health globally. Disruption of energy balance in the body leads to the development of metabolic syndromes, with fatty acid-binding GPCRs playing a key role in regulating energy homeostasis. Understanding the biological functions of these GPCRs in the gut, pancreas, and adipose tissue can help identify novel pharmacological targets for treating metabolic diseases.

NUTRITION REVIEWS (2022)

Add to Collection
Article Biology

Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

Natasja Barki et al.

Summary: Volatile small molecules, including SCFAs, can act on the body in a hormone-like manner through specific GPCRs. FFA2 and FFA3 are the primary GPCR targets for SCFAs. They have distinct functions and regulate cellular activity and calcium levels through different mechanisms and signaling pathways in the gut and nervous system.

ELIFE (2022)

Add to Collection
Article Multidisciplinary Sciences

Protective effects of different Bacteroides vulgatus strains against lipopolysaccharide-induced acute intestinal injury, and their underlying functional genes

Chen Wang et al.

Summary: This study assessed the protective role of Bacteroides vulgatus strains in LPS-induced acute intestinal injury in mice. They found that B. vulgatus FTJS7K1 strain protected the intestinal epithelium and regulated the cytokine production and gut microbiota structure. These findings support the screening of Bacteroides genus for potential probiotics.

JOURNAL OF ADVANCED RESEARCH (2022)

Add to Collection
Article Medicine, General & Internal

Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis

Li Zhang et al.

Summary: This study reveals that hepatic ketogenesis is activated as an endogenous protective program to restrain the progression of acute pancreatitis, indicating its potential therapeutic value.

EBIOMEDICINE (2022)

Add to Collection
Article Microbiology

Paneth Cells Protect against Acute Pancreatitis via Modulating Gut Microbiota Dysbiosis

Yang Fu et al.

Summary: We demonstrate that dysfunction of Paneth cells is observed in patients with acute pancreatitis (AP) and experimental AP mice. Our in vivo research reveals that long-term dysfunction of Paneth cells exacerbates the severity of AP and is associated with dysbiosis of gut microbiota. Restoring part of Paneth cell functions through lysozyme supplementation alleviates the severity of AP and gut microbiota dysbiosis. This study provides novel insight into the link of pancreas-gut interactions in the pathogenesis of AP, providing a new direction for the clinical treatment of intestinal complications during AP.

MSYSTEMS (2022)

Add to Collection
Article Nutrition & Dietetics

SCFA: mechanisms and functional importance in the gut

Camille Martin-Gallausiaux et al.

Summary: This article discusses the mechanisms and impact of short-chain fatty acids (SCFA) on gut functions, host immunity, and human health. SCFA, derived from bacterial fermentation of dietary fibers, serve as important fuels for intestinal epithelial cells and modulate various functions to impact intestinal homeostasis.

PROCEEDINGS OF THE NUTRITION SOCIETY (2021)

Add to Collection
Article Agriculture, Multidisciplinary

Okra pectin relieves inflammatory response and protects damaged intestinal barrier in caerulein-induced acute pancreatic model

Baoyi Xiong et al.

Summary: The study demonstrated that okra pectin can attenuate inflammation caused by acute pancreatitis by protecting the intestinal barrier, with OP showing better efficacy than COP. Dietary supplementation of OP could effectively interfere with intestinal damage and attenuate inflammatory responses triggered by AP.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2021)

Add to Collection
Article Gastroenterology & Hepatology

Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate

Fons F. van den Berg et al.

Summary: The gut microbiota plays a central role in necrotising pancreatitis, with a Western-type diet leading to increased mortality and bacterial dissemination. Butyrate supplementation can reverse these effects, while antibiotic decontamination reduces mortality but increases Gram-positive dissemination. Patients with acute pancreatitis show depleted butyrate producers, indicating a potential role of butyrate in disease progression.

GUT (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

Fermentation of prebiotics by human colonic microbiotain vitroand short-chain fatty acids production: a critical review

T. J. Ashaolu et al.

Summary: This review critically evaluates the impact of dietary fibers and prebiotics on the gastrointestinal microbiota in vitro, highlighting their positive effects on gut health and the production of short-chain fatty acids. The study discusses the molecular signaling mechanisms associated with prebiotic substrates and the phenotypic responses related to gut microbe composition. Additionally, it explains the potential health benefits of common dietary fibers and how they affect the in vitro human colonic fermentation.

JOURNAL OF APPLIED MICROBIOLOGY (2021)

Add to Collection
Article Oncology

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

Yansen Xiao et al.

Summary: The study reveals that tumor-secreted protease CTSC promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.

CANCER CELL (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Butyrate Protects Pancreatic Beta Cells from Cytokine-Induced Dysfunction

Michala Prause et al.

Summary: Butyrate has been shown to prevent cytokine-induced dysfunction in pancreatic beta cells, potentially reducing the impact of inflammation in the progression of T2D. However, it may also affect cell proliferation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Chemistry, Applied

Pectin in diet: Interactions with the human microbiome, role in gut homeostasis, and nutrient-drug interactions

Mostafa S. Elshahed et al.

Summary: Pectins are indigestible polysaccharides that can be degraded by gut bacteria, producing short chain fatty acids. Understanding how pectins function as prebiotics in the gut can help target beneficial bacteria and favor a balanced microbiota community for maximizing health benefits.

CARBOHYDRATE POLYMERS (2021)

Add to Collection
Review Peripheral Vascular Disease

Gut Microbiota-Derived Short-Chain Fatty Acids Facilitate Microbiota:Host Cross talk and Modulate Obesity and Hypertension

Haley B. Overby et al.

Summary: This review highlights the role of short-chain fatty acids (SCFAs) in mediating communication between the host and gut microbiota, as well as their effects on obesity and hypertension. SCFA production within the intestine affects intestinal pH, microbial composition, and host metabolism, ultimately influencing inflammation and metabolic disorders.

CURRENT HYPERTENSION REPORTS (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators

Manuel Grundmann et al.

Summary: The physiological function of free fatty acids has been redefined with the discovery that they can also act as signaling molecules at FFA receptors. Researchers are exploring allosteric ligands targeting FFARs to develop drugs for various diseases, aiming to leverage the potential of GPCRs in drug discovery.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Gastroenterology & Hepatology

Traditional Chinese Medicine Formulas Alleviate Acute Pancreatitis Pharmacological Activities and Mechanisms

Chuting Yang et al.

Summary: Traditional Chinese medicine has unique advantages in treating acute pancreatitis, improving the condition of patients by regulating inflammatory responses and enhancing immunity, thereby reducing mortality rates and financial burdens.

PANCREAS (2021)

Add to Collection
Review Pharmacology & Pharmacy

The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis

Pinyi Liu et al.

Summary: Short-chain fatty acids (SCFAs), produced during bacterial fermentation of dietary fiber, play crucial roles in regulating inflammation, carcinogenesis, intestinal barrier function, and oxidative stress. Their signaling mechanisms involve histone acetylation promotion and activation of G-protein-coupled receptors. SCFAs have a wide range of positive effects and show high therapeutic potential in human-related diseases.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection
Article Gastroenterology & Hepatology

Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1-induced inflammation

Chang-Ju Zhu et al.

Summary: The study aimed to investigate the role of Cal in SAP-ALI and its underlying mechanism. Results showed that Cal can protect mice against L-arg-induced SAP and associated ALI by attenuating local and systemic neutrophil infiltration and inflammatory response via inhibition of HMGB1 and the NF-kappa B signaling pathway.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Add to Collection
Article Cell Biology

Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury

Lingming Kong et al.

Summary: This study demonstrates that SIT reduces oxidative stress and excessive autophagy in SAP-ALI through the p62-Keap1-Nrf2 signaling pathway and nuclear translocation of Nrf2. However, the anti-inflammatory effect of SIT is reduced in Nrf2 knockout mice and Nrf2-knockdown BEAS-2B cells, leading to ROS accumulation and excessive autophagy.

CELL DEATH & DISEASE (2021)

Add to Collection
Review Cell Biology

Macrophages in Lung Injury, Repair, and Fibrosis

Peiyong Cheng et al.

Summary: Fibrosis progression in the lung can lead to impaired gas exchange, respiratory failure, or even death. Macrophages play a crucial role in response to lung injury, repair, and fibrosis, with their activation and polarization being key factors in the process. Targeting macrophages may offer potential benefits in alleviating pulmonary fibrosis.

CELLS (2021)

Add to Collection
Article Physiology

Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression

Qing Liu et al.

Summary: This study found that microbial metabolites produced by the gut microbiome can influence lung physiology and injury responses through modifying the metabolic programming of lung macrophages. The gut microbiota, specifically those which produce SCFA, may play a crucial role in establishing and regulating lung immune tone by transmitting certain factors to the lung. Additionally, SCFA receptors in lung cells show distinct expression patterns and responses to external stimuli, highlighting the complex interaction between gut microbiome-derived factors and lung immune activity.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

Add to Collection
Review Microbiology

A short chain fatty acid-centric view of Clostridioides difficile pathogenesis

Anna L. Gregory et al.

Summary: Clostridioides difficile is an opportunistic diarrheal pathogen with significant global morbidity and mortality. Disrupted gut microbiome, often caused by antibiotic treatment, is the primary risk factor for C. difficile infection, emphasizing the critical role of C. difficile-microbiome interactions. Short chain fatty acids (SCFAs) in the gut, produced by the gut microbiome, have impacts on the host and C. difficile biology. Understanding the relationship between C. difficile and SCFAs may lead to new approaches for managing C. difficile infection and other gastrointestinal pathogens.

PLOS PATHOGENS (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

Understanding the Effects of Metabolites on the Gut Microbiome and Severe Acute Pancreatitis

Shijie Ye et al.

Summary: Acute pancreatitis is an inflammatory disease of the pancreas with severity classified as mild, moderately severe, or severe. Infection-related complications are the main causes of mortality in patients. The metabolic activities of intestinal microbiota play a crucial role in disease progression.

BIOMED RESEARCH INTERNATIONAL (2021)

Add to Collection
Review Immunology

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

Chang H. Kim

Summary: Dietary fiber metabolites, particularly short-chain fatty acids, play crucial roles in maintaining immune system balance, regulating host metabolism, intestinal functions, and immunity system.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Add to Collection
Article Agriculture, Dairy & Animal Science

Quality characteristics of yogurts fermented with short-chain fatty acid-producing probiotics and their effects on mucin production and probiotic adhesion onto human colon epithelial cells

Y. H. Chang et al.

Summary: This study found that yogurt fermented with different combinations of probiotics exhibited significantly higher acetate levels than the control group yogurt. Treatment of colon epithelial cells with the yogurt supernatants resulted in an increase in mucin protein production, enhancing the protective function of the intestinal epithelium.

JOURNAL OF DAIRY SCIENCE (2021)

Add to Collection
Article Cell Biology

Treatment of Severe Acute Pancreatitis and Related Lung Injury by Targeting Gasdermin D-Mediated Pyroptosis

Jinxiang Wu et al.

Summary: This study revealed the role of GSDMD-mediated pyroptosis in SAP-associated lung injury, and demonstrated the potential application of disulfiram as a pyroptosis inhibitor in the treatment of SAP.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection
Article Immunology

Shotgun metagenomics reveals significant gut microbiome features in different grades of acute pancreatitis

Shanshan Yu et al.

Summary: The study demonstrated a potential association between the composition and function of the gut microbiota and the progression of AP severity.AP patients showed decreased species richness in their gut microbiota, with different representative microbial species in different severity grades of AP. The study also identified specific metabolic pathways associated with AP severity in different grades of AP patients.

MICROBIAL PATHOGENESIS (2021)

Add to Collection
Article Gastroenterology & Hepatology

Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome

Xue-Ying Liang et al.

Summary: This study analyzed the relationship between intestinal bacterial overgrowth and ALI/ARDS in 150 patients with AP. The results showed that intestinal bacterial overgrowth in the early stage of SAP is correlated with ARDS.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Add to Collection
Review Nutrition & Dietetics

Short-Chain Fatty Acids, Maternal Microbiota and Metabolism in Pregnancy

Maciej Zietek et al.

Summary: This study summarizes the potential impact and mechanisms of SCFAs on maternal metabolism during pregnancy, emphasizing their crucial role in maternal health and neonatal development. Additionally, it also discusses the mechanisms of SCFAs as signaling molecules regulating the body's energy balance through G-protein receptors.

NUTRIENTS (2021)

Add to Collection
Article Multidisciplinary Sciences

High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism

Yoon Ok Jang et al.

Summary: High-fiber diets can influence cigarette smoking-exposed emphysema mice by modulating gut microbiota and metabolites, slowing down pathological changes and inflammatory responses. Different types of dietary fiber can also impact gut microbiota diversity and metabolism.

SCIENTIFIC REPORTS (2021)

Add to Collection
Review Physiology

Participation of Short-Chain Fatty Acids and Their Receptors in Gut Inflammation and Colon Cancer

Maria Daniella Carretta et al.

Summary: Short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fiber play a critical role in maintaining intestinal health, have anti-inflammatory and anti-cancer effects, and signal through various receptors. A fiber-rich diet is associated with reduced risk of colon cancer and clinical benefits for patients with IBD.

FRONTIERS IN PHYSIOLOGY (2021)

Add to Collection
Review Medicine, General & Internal

Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

Sara Deleu et al.

Summary: Short-chain fatty acids play important roles in the gut microbiome and intestinal immune system, exerting various effects on host metabolism and immune system. Further research is needed on the cross-feeding mechanisms in the gut microbiome and the therapeutic potential of SCFAs in different disease models.

EBIOMEDICINE (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Variations in Gut Microbiome Are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis

Xiaomin Hu et al.

Summary: HTGAP patients have higher rates of severe AP, organ failure, and longer hospital stays compared to non-HTGAP patients. Changes in gut microbiota are associated with disease severity and poor prognosis in HTGAP patients, suggesting a potential link between gut microbiota and hypertriglyceridemia-related acute pancreatitis.

BIOMOLECULES (2021)

Add to Collection
Article Gastroenterology & Hepatology

Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency

Yuying Liu et al.

Summary: In the treatment of Treg-deficiency-induced autoimmunity, Limosilactobacillus reuteri DSM 17938 (LR) showed greater efficacy than Lacticaseibacillus rhamnosus GG (LGG). The study demonstrated that two different probiotics produce distinct signatures in the fecal microbial community in mice with Treg deficiency, but with many similarities in global plasma metabolites in general. However, there are strain-specific microbial products with different anti-inflammatory properties, reinforcing the concept that one size does not fit all in the treatment of autoimmune disease.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

Add to Collection
Review Allergy

The Dietary Fiber Pectin: Health Benefits and Potential for the Treatment of Allergies by Modulation of Gut Microbiota

Frank Blanco-Perez et al.

Summary: The incidence of allergies is increasing and has been associated with environmental factors such as westernized diets. Changes in environment and nutrition can lead to dysbiosis of microbiota, affecting the production of microbial metabolites and potentially causing epigenetic modifications. Studies have shown that pectin, a dietary fiber, may have immunomodulatory effects on allergies by altering gut and lung microbiota, increasing the concentrations of short chain fatty acids, and suppressing inflammatory responses.

CURRENT ALLERGY AND ASTHMA REPORTS (2021)

Add to Collection
Article Gastroenterology & Hepatology

Novel Circulating and Tissue Monocytes as Well as Macrophages in Pancreatitis and Recovery

Murli Manohar et al.

Summary: The study identified several novel monocyte/macrophage subsets with unique phenotype and functional characteristics associated with acute pancreatitis (AP), recovery, and severe acute pancreatitis (SAP). The findings highlight the differential innate immune responses during AP progression and recovery that can be valuable for future disease monitoring and targeting.

GASTROENTEROLOGY (2021)

Add to Collection
Article Biochemistry & Molecular Biology

The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension

Vijaya Karoor et al.

Summary: Butyrate shows protective effects in a rat model of hypoxic pulmonary hypertension by preventing pulmonary vascular remodeling and increased permeability, reducing right ventricular hypertrophy, and increasing histone H3 acetylation. Additionally, it modulates cytokine profiles in lung tissue and upregulates tight junctional proteins in endothelial cells, suggesting its potential as a complementary treatment for PH and other cardiovascular diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

The Intestinal Microbiota: Impacts of Antibiotics Therapy, Colonization Resistance, and Diseases

Taif Shah et al.

Summary: Trillions of microbes coevolved with the human host in the gastrointestinal tract, forming a mutually beneficial relationship. The intestinal microbiome plays a key role in inhibiting the growth of pathogenic microbes through fermentation and production of antimicrobial metabolites. Exposure to antibiotics can trigger a resistome response, affecting colonization resistance and impacting pathogen colonization and diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Leaky Gut: Effect of Dietary Fiber and Fats on Microbiome and Intestinal Barrier

Haruki Usuda et al.

Summary: The intestinal tract acts as a barrier preventing harmful molecules from invading mucosal tissue, with intestinal permeability serving as an index for intestinal barrier integrity. Increased intestinal permeability is associated with various diseases, and chronic increase leads to 'leaky gut,' observed in patients and animal models. Nutrients play a key role in influencing intestinal permeability and the microbiome for a better understanding of leaky gut and its potential mechanisms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Gastroenterology & Hepatology

Gut microbiome in acute pancreatitis: A review based on current literature

Bharati Kadamb Patel et al.

Summary: The gut microbiome plays a significant role in acute pancreatitis, with maintaining microbial balance potentially reducing systemic effects. Supplementing with prebiotics, synbiotics, and probiotics could be crucial in AP treatment.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Add to Collection
Article Multidisciplinary Sciences

Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway

Shujun Yang et al.

Summary: Daphnetin pretreatment significantly alleviated SAP-induced pancreatic and lung tissue damage by inhibiting the activation of the JAK2-STAT3 signaling pathway, reducing inflammatory cytokine concentrations, decreasing cell apoptosis, and inhibiting white blood cell infiltration.

SCIENTIFIC REPORTS (2021)

Add to Collection
Review Physiology

Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins

Diliana Perez-Reytor et al.

Summary: Short-chain fatty acids (SCFAs) produced by gut microbial anaerobic fermentation can activate signaling cascades and increase intestinal barrier integrity. They inhibit the virulence of enteric pathogens and have protective effects against bacterial colonization.

FRONTIERS IN PHYSIOLOGY (2021)

Add to Collection
Review Immunology

Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier

Shanshan Chen et al.

Summary: The intestinal mucosal immune barrier protects the host from pathogenic microorganisms, with immune cells and cytokines maintaining homeostasis. Exosomal lncRNAs play a role in immune cell differentiation and modulating the immune response, potentially impacting intestinal illnesses.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

Add to Collection
Article Immunology

Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides

Julia Beisner et al.

Summary: This study showed that supplementation with inulin or sodium butyrate improved diet-induced liver steatosis in obese mice, reduced weight gain, liver weight, plasma and hepatic triglyceride levels. The supplementation also induced expression of Paneth cell antimicrobials, contributing to improved intestinal barrier function.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection
Article Immunology

Propionic Acid Rescues High-Fat Diet Enhanced Immunopathology in Autoimmunity via Effects on Th17 Responses

Stefanie Haase et al.

Summary: High-fat diets are linked to obesity and autoimmune diseases, with short-chain fatty acid propionate showing potential in counteracting the pro-inflammatory state induced by high-fat diets. By enhancing regulatory T cell functionality, propionate can prevent disease progression.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection
Article Microbiology

Gut microbiome variation modulates the effects of dietary fiber on host metabolism

Sofia M. Murga-Garrido et al.

Summary: This study demonstrates a causal link between interindividual variation in gut microbiome and differential effects of dietary fiber on host metabolic phenotypes, suggesting that a one-fits-all fiber supplementation approach to promote health is unlikely to elicit consistent effects across individuals. The findings underscore the importance of microbe-diet interactions on host metabolism and suggest that gut microbes modulate dietary fiber efficacy.

MICROBIOME (2021)

Add to Collection
Article Microbiology

Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration

Yuanyuan Lei et al.

Summary: Heparanase exacerbates acute pancreatitis through its interaction with the gut microbiota, particularly the commensal Parabacteroides. In addition, Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis by reducing neutrophil infiltration, suggesting a potential therapeutic strategy for acute pancreatitis.

MICROBIOME (2021)

Add to Collection
Review Cell Biology

Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease

Pooja S. Salvi et al.

Summary: Butyrate acts as a link between the intestinal microbiome and epithelium, affecting colon, tumors, stem cells, and inflammatory diseases differently. It also regulates cellular inflammation, antigen tolerance, and the pathogenesis of intestinal diseases.

CELLS (2021)

Add to Collection
Review Immunology

Comprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury-A Narrative Review

YaLan Luo et al.

Summary: Acute pancreatitis (AP) is a common acute abdominal inflammatory disease with about 20% of patients progressing to severe acute pancreatitis (SAP), leading to systemic inflammatory response syndrome and multiple organ dysfunction syndrome. SAP often presents with associated cardiac injury (SACI), the molecular mechanisms of which remain poorly understood.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Baicalin inhibits APEC-induced lung injury by regulating gut microbiota and SCFA production

Lu-Yuan Peng et al.

Summary: The study found that baicalin protected against APEC infection by modulating gut microbiota, increasing short chain fatty acid (SCFA) production, especially acetate. Acetate may circulate to the lungs to activate FFAR2 to defend against APEC infection.

FOOD & FUNCTION (2021)

Add to Collection
Article Gastroenterology & Hepatology

Emodin Alleviates Intestinal Barrier Dysfunction by Inhibiting Apoptosis and Regulating the Immune Response in Severe Acute Pancreatitis

Qi Zhou et al.

Summary: This study confirmed the protective effect of emodin on intestinal function and its involvement in the immune response in SAP, shedding light on the mechanisms underlying the regulation of the intestinal barrier and immune response by emodin.

PANCREAS (2021)

Add to Collection
Review Gastroenterology & Hepatology

Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols

Kate R. Secombe et al.

Summary: The systematic review identified inconsistencies and incompleteness in reporting of preclinical FMT protocols in mouse models. To address these limitations, Guidelines for Reporting Animal Fecal Transplant (GRAFT) were developed to improve the quality of reporting and peer review in preclinical FMT studies.

GUT MICROBES (2021)

Add to Collection
Article Gastroenterology & Hepatology

Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease

Gengfeng Li et al.

Summary: Host-microbial cross-talk is important for gut homeostasis. Butyrate was found to inhibit proinflammatory responses of neutrophils in IBD and may have therapeutic potential. The mechanism of action involves HDAC inhibition and modulation of neutrophil functions.

GUT MICROBES (2021)

Add to Collection
Article Gastroenterology & Hepatology

Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor

Ruth X. Wang et al.

Summary: The gut microbiota plays a crucial role in human health by providing short-chain fatty acids (SCFAs), particularly butyrate, which contribute to gut homeostasis and disease resistance. Butyrate is shown to directly inhibit hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) to stabilize HIF, offering potential therapeutic impact. Microbiota-derived butyrate is essential for stabilizing HIF in murine colonic tissue, suggesting a co-evolution of mammals and mutualistic microbiota in impacting critical gene regulation pathways.

GUT MICROBES (2021)

Add to Collection
Article Gastroenterology & Hepatology

Hepatic Adenosine Triphosphate Reduction Through the Short-Chain Fatty Acids-Peroxisome Proliferator-Activated Receptor γ-Uncoupling Protein 2 Axis Alleviates Immune-Mediated Acute Hepatitis in Inulin-Supplemented Mice

Akihiro Yamaguchi et al.

Summary: It has been found that dietary supplementation of inulin can alleviate acute immune-mediated liver injury induced by ConA in mice, possibly through the SCFA-PPAR gamma-UCP2 axis. Changes in gut microbiota, such as increased operational taxonomic units in genera Akkermansia and Allobaculum, are also associated with the protective effect.

HEPATOLOGY COMMUNICATIONS (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

The roles of microbial products in the development of colorectal cancer: a review

Yongkun Fang et al.

Summary: A large number of microbes in the gut play a role in processing ingested food, and their products are implicated in the development of colorectal cancer. The molecular mechanisms linking gut microbial products to CRC are not fully understood, with some products having controversial roles in CRC. Investigating the effects of gut microbiota products on CRC and their mechanisms is crucial for prevention and treatment.

BIOENGINEERED (2021)

Add to Collection
Article Gastroenterology & Hepatology

Intestinal Inflammation Modulates the Epithelial Response to Butyrate in Patients With Inflammatory Bowel Disease

Elena Ferrer-Picon et al.

INFLAMMATORY BOWEL DISEASES (2020)

Add to Collection
Review Physiology

FREE FATTY ACID RECEPTORS IN HEALTH AND DISEASE

Ikuo Kimura et al.

PHYSIOLOGICAL REVIEWS (2020)

Add to Collection
Article Gastroenterology & Hepatology

Identification of Dysfunctional Gut Microbiota Through Rectal Swab in Patients with Different Severity of Acute Pancreatitis

Shanshan Yu et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

Add to Collection
Article Immunology

Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice

Zhen Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Add to Collection
Article Biotechnology & Applied Microbiology

Protective effect of baicalin on the regulation of Treg/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis

Lei Zhu et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Add to Collection
Article Cell Biology

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

Elizabeth C. Rosser et al.

CELL METABOLISM (2020)

Add to Collection
Review Immunology

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks

Raphael Enaud et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Add to Collection
Article Nutrition & Dietetics

Meta-Analysis of Efficacy of Rhubarb Combined With Early Enteral Nutrition for the Treatment of Severe Acute Pancreatitis

Xinrong Chen et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2020)

Add to Collection
Article Multidisciplinary Sciences

Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity

Sangman M. Kim et al.

NATURE COMMUNICATIONS (2020)

Add to Collection
Article Biochemical Research Methods

Proteomic analysis reveals the protective effects of emodin on severe acute pancreatitis induced lung injury by inhibiting neutrophil proteases activity

Caiming Xu et al.

JOURNAL OF PROTEOMICS (2020)

Add to Collection
Review Nutrition & Dietetics

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

Paulina Markowiak-Kopec et al.

NUTRIENTS (2020)

Add to Collection
Review Immunology

Bacterial biofilm in colorectal cancer: What is the real mechanism of action?

Rasoul Mirzaei et al.

MICROBIAL PATHOGENESIS (2020)

Add to Collection
Review Cell Biology

Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

Xuxin Chen et al.

INFLAMMATION RESEARCH (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

Rashi Singhal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Add to Collection
Article Endocrinology & Metabolism

SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD

Mingjuan Deng et al.

JOURNAL OF ENDOCRINOLOGY (2020)

Add to Collection
Article Biochemistry & Molecular Biology

PAD4 Deficiency Improves Bleomycin-induced Neutrophil Extracellular Traps and Fibrosis in Mouse Lung

Masaki Suzuki et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Add to Collection
Article Cell Biology

Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling

Wei Huang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Add to Collection
Article Microbiology

Short-Chain Fatty Acid Production by Gut Microbiota from Children with Obesity Differs According to Prebiotic Choice and Bacterial Community Composition

Zachary C. Holmes et al.

MBIO (2020)

Add to Collection
Article Cell Biology

mTOR-Myc axis drives acinar-to-dendritic cell transition and the CD4+ T cell immune response in acute pancreatitis

Dan Xu et al.

CELL DEATH & DISEASE (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism

Jin He et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection
Article Microbiology

Prebiotics and Community Composition Influence Gas Production of the Human Gut Microbiota

Xiaoqian Yu et al.

MBIO (2020)

Add to Collection
Article Multidisciplinary Sciences

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Wenjing Yang et al.

NATURE COMMUNICATIONS (2020)

Add to Collection
Review Immunology

Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells is Essential to Maintain Lung Homeostasis

Elyse Y. Bissonnette et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Porous COS@SiO2Nanocomposites Ameliorate Severe Acute Pancreatitis and Associated Lung Injury by Regulating the Nrf2 Signaling Pathway in Mice

Qixiang Mei et al.

FRONTIERS IN CHEMISTRY (2020)

Add to Collection
Article Gastroenterology & Hepatology

Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota

Florence Fischer et al.

GUT MICROBES (2020)

Add to Collection
Review Medicine, Research & Experimental

Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis

Peng Ge et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection
Article Immunology

Physiological concentrations of short-chain fatty acids induce the formation of neutrophil extracellular traps in vitro

Liliana Iniguez-Gutierrez et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2020)

Add to Collection
Article Developmental Biology

The short-chain fatty acids butyrate and propionate protect against inflammation-induced activation of mediators involved in active labor: implications for preterm birth

Hope Eveline Carter Moylan et al.

MOLECULAR HUMAN REPRODUCTION (2020)

Add to Collection
Article Agriculture, Dairy & Animal Science

Resistant starch reduces large intestinal pH and promotes fecal lactobacilli and bifidobacteria in pigs

B. U. Metzler-Zebeli et al.

ANIMAL (2019)

Add to Collection
Article Endocrinology & Metabolism

Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2

Attilio Pingitore et al.

DIABETES OBESITY & METABOLISM (2019)

Add to Collection
Article Plant Sciences

Rhubarb Peony Decoction ameliorates ulcerative colitis in mice by regulating gut microbiota to restoring Th17/Treg balance

Shuang Luo et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

Add to Collection
Article Microbiology

Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice

Xiaoli Tian et al.

FRONTIERS IN MICROBIOLOGY (2019)

Add to Collection
Article Medicine, Research & Experimental

Intraperitoneal Injection of Acetate Protects Mice Against lipopolysaccharide (LPS)-Induced Acute Lung Injury Through Its Anti-Inflammatory and Anti-Oxidative Ability

Mengda Xu et al.

MEDICAL SCIENCE MONITOR (2019)

Add to Collection
Review Gastroenterology & Hepatology

The role of short-chain fatty acids in microbiota-gut-brain communication

Boushra Dalile et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Add to Collection
Article Pharmacology & Pharmacy

Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms

Xiaohua Pan et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Add to Collection
Review Emergency Medicine

2019 WSES guidelines for the management of severe acute pancreatitis

Ari Leppaniemi et al.

WORLD JOURNAL OF EMERGENCY SURGERY (2019)

Add to Collection
Review Immunology

Microbiota-Immune Interaction in the Pathogenesis of Gut-Derived Infection

Chenyang Wang et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection
Article Immunology

SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

Yu Zhou et al.

INFLAMMOPHARMACOLOGY (2019)

Add to Collection
Review Microbiology

Bacterial translocation in acute pancreatitis

Jinbo Liu et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2019)

Add to Collection
Review Biochemistry & Molecular Biology

The Role of the Microbiome in Asthma: The Gut-Lung Axis

Franco Frati et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection
Article Agriculture, Multidisciplinary

Sodium Butyrate Inhibits the Inflammation of Lipopolysaccharide-Induced Acute Lung Injury in Mice by Regulating the Toll-Like Receptor 4/Nuclear Factor κB Signaling Pathway

Jing Liu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Add to Collection
Article Gastroenterology & Hepatology

Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice

Yin Zhu et al.

JOURNAL OF GASTROENTEROLOGY (2019)

Add to Collection
Article Nutrition & Dietetics

Higher Fecal Short-Chain Fatty Acid Levels Are Associated with Gut Microbiome Dysbiosis, Obesity, Hypertension and Cardiometabolic Disease Risk Factors

Jacobo de la Cuesta-Zuluaga et al.

NUTRIENTS (2019)

Add to Collection
Article Microbiology

Bioactive factors secreted by Bifidobacterium breve B-3 enhance barrier function in human intestinal Caco-2 cells

Y. Kurose et al.

BENEFICIAL MICROBES (2019)

Add to Collection
Review Immunology

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Daniela Parada Venegas et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection
Article Cell Biology

Hsp90 regulation affects the treatment of glucocorticoid for pancreatitis-induced lung injury

Yan Zhao et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2018)

Add to Collection
Article Immunology

Sodium butyrate alleviates LPS-induced acute lung injury in mice via inhibiting HMGB1 release

Na Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

Add to Collection
Article Immunology

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

Ye Zhao et al.

MUCOSAL IMMUNOLOGY (2018)

Add to Collection
Article Multidisciplinary Sciences

Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells

Camille Martin-Gallausiaux et al.

SCIENTIFIC REPORTS (2018)

Add to Collection
Review Nutrition & Dietetics

Butyrate: A Double-Edged Sword for Health?

Hu Liu et al.

ADVANCES IN NUTRITION (2018)

Add to Collection
Article Pharmacology & Pharmacy

Free Total Rhubarb Anthraquinones Protect Intestinal Injury via Regulation of the Intestinal Immune Response in a Rat Model of Severe Acute Pancreatitis

Yuxia Xiong et al.

FRONTIERS IN PHARMACOLOGY (2018)

Add to Collection
Article Cell Biology

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

Yanhai Feng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Add to Collection
Article Physiology

Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis

Sathish Sivaprakasam et al.

COMPREHENSIVE PHYSIOLOGY (2018)

Add to Collection
Review Gastroenterology & Hepatology

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

Mingming Sun et al.

JOURNAL OF GASTROENTEROLOGY (2017)

Add to Collection
Article Neurosciences

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

Eef Boets et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

Add to Collection
Article Immunology

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

W. Wu et al.

MUCOSAL IMMUNOLOGY (2017)

Add to Collection
Review Peripheral Vascular Disease

Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?

Hideo Ohira et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2017)

Add to Collection
Article Immunology

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2

Leon Zheng et al.

JOURNAL OF IMMUNOLOGY (2017)

Add to Collection
Article Surgery

Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance

George Kasotakis et al.

Journal of Trauma and Acute Care Surgery (2017)

Add to Collection
Article Food Science & Technology

Low-methoxyl lemon pectin attenuates inflammatory responses and improves intestinal barrier integrity in caerulein-induced experimental acute pancreatitis

Yajun Sun et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2017)

Add to Collection
Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Glenn R. Gibson et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Add to Collection
Article Multidisciplinary Sciences

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

Mariana X. Byndloss et al.

SCIENCE (2017)

Add to Collection
Article Surgery

Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance

George Kasotakis et al.

Journal of Trauma and Acute Care Surgery (2017)

Add to Collection
Review Microbiology

Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction

Yael Litvak et al.

CURRENT OPINION IN MICROBIOLOGY (2017)

Add to Collection
Article Immunology

Short-Chain Fatty Acids Regulate Cytokines and Th17/Treg Cells in Human Peripheral Blood Mononuclear Cells in vitro

M. Asarat et al.

IMMUNOLOGICAL INVESTIGATIONS (2016)

Add to Collection
Article Multidisciplinary Sciences

Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion

Franziska Faber et al.

NATURE (2016)

Add to Collection
Review Pharmacology & Pharmacy

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis

Sathish Sivaprakasam et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Add to Collection
Article Multidisciplinary Sciences

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids

Jung-ha Park et al.

PLOS ONE (2016)

Add to Collection
Review Microbiology

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

David Rios-Covian et al.

FRONTIERS IN MICROBIOLOGY (2016)

Add to Collection
Article Pharmacology & Pharmacy

Propionate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress

Ling-chang Tong et al.

FRONTIERS IN PHARMACOLOGY (2016)

Add to Collection
Article Microbiology

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome

Robert P. Dickson et al.

NATURE MICROBIOLOGY (2016)

Add to Collection
Article Nutrition & Dietetics

Down-regulation of monocarboxylate transporter 1 (MCT1) gene expression in the colon of piglets is linked to bacterial protein fermentation and pro-inflammatory cytokine-mediated signalling

Carmen Villodre Tudela et al.

BRITISH JOURNAL OF NUTRITION (2015)

Add to Collection
Article Gastroenterology & Hepatology

Sodium Butyrate Reduces Organ Injuries in Mice with Severe Acute Pancreatitis Through Inhibiting HMGB1 Expression

Ting Zhang et al.

DIGESTIVE DISEASES AND SCIENCES (2015)

Add to Collection
Review Endocrinology & Metabolism

Short-chain fatty acids in control of body weight and insulin sensitivity

Emanuel E. Canfora et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Add to Collection
Article Multidisciplinary Sciences

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Laurence Macia et al.

NATURE COMMUNICATIONS (2015)

Add to Collection
Article Nutrition & Dietetics

Quantification of in Vivo Colonic Short Chain Fatty Acid Production from Inulin

Eef Boets et al.

NUTRIENTS (2015)

Add to Collection
Article Multidisciplinary Sciences

Remodeling of Tight Junctions and Enhancement of Barrier Integrity of the CACO-2 Intestinal Epithelial Cell Layer by Micronutrients

Mary Carmen Valenzano et al.

PLOS ONE (2015)

Add to Collection
Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Colin Hill et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

Add to Collection
Article Cardiac & Cardiovascular Systems

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

E. C. Aguilar et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2014)

Add to Collection
Article Gastroenterology & Hepatology

Intravenous infusion of mesenteric lymph from severe intraperitoneal infection rats causes lung injury in healthy

Yan-Min Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Add to Collection
Review Immunology

Regional specialization within the intestinal immune system

Allan M. Mowat et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Add to Collection
Article Multidisciplinary Sciences

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Nicholas Arpaia et al.

NATURE (2013)

Add to Collection
Article Multidisciplinary Sciences

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Koji Atarashi et al.

NATURE (2013)

Add to Collection
Article Multidisciplinary Sciences

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

Patrick M. Smith et al.

SCIENCE (2013)

Add to Collection
Article Cell Biology

Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells

Lu Liu et al.

CELLULAR IMMUNOLOGY (2012)

Add to Collection
Article Gastroenterology & Hepatology

Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

Hong-Bo Wang et al.

DIGESTIVE DISEASES AND SCIENCES (2012)

Add to Collection
Review Food Science & Technology

Relevance of protein fermentation to gut health

Karen Windey et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2012)

Add to Collection
Article Multidisciplinary Sciences

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Koji Atarashi et al.

SCIENCE (2011)

Add to Collection
Article Biochemistry & Molecular Biology

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

Nanda Burger-van Paassen et al.

BIOCHEMICAL JOURNAL (2009)

Add to Collection
Article Gastroenterology & Hepatology

Acute Pancreatitis Hypertonic Saline Increases Heat Shock Proteins 70 and 90 and Reduces Neutrophil Infiltration in Lung Injury

Ana Iochabel Soares Moretti et al.

PANCREAS (2009)

Add to Collection
Article Gastroenterology & Hepatology

Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E2 and cytokines

Mary Ann Cox et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.