Journal
PHARMACOGENOMICS
Volume 23, Issue 10, Pages 575-583Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/pgs-2022-0052
Keywords
antipsychotics; pharmacogenetics; risperidone response; schizophrenia; TNIK
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Funding
- Foundation of Brain Science and Brain-Like Intelligence Technology [2021ZD0201904]
- Foundation of CRC Shanghai Mental Health Center [CRC2021ZD02]
- National Key Research and Development Program of China [2016YFC1307005]
- Foundation of Shanghai Mental Health Center Sailing Plan [2018-QH-05]
- National Natural Science Foundation of China [81971257]
- Natural Science Foundation of Shanghai [17ZR1424600, 20ZR1448400]
- Foundation of Shanghai Jiao Tong University School of Medicine [16XJ21010]
- Shanghai Clinical Research Center for Mental Health [19MC1911100]
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This study revealed an association between the rs2088885 and rs7627954 SNPs of the TNIK gene and risperidone treatment response.
Aim: To investigate whether the TNIK gene affects risperidone treatment outcomes in the Chinese population. Methods: A total of 148 unrelated inpatients who received risperidone for six weeks were enrolled. The selected single nucleotide polymorphisms (SNPs; rs2088885, rs7627954 and rs13065441) were genotyped using the MassARRAY (R) SNP IPLEX platform. Results: The analysis showed that one novel SNP of TNIK, rs7627954, had a significant association with the response to risperidone (chi(2) = 4.472; p = 0.034). This work also identified rs2088885 as significantly associated with risperidone response (chi(2) = 5.257; p = 0.022). The result revealed that the rs2088885-rs7627954 C-T haplotype was more prevalent in good responders than in poor responders (p = 0.0278). Conclusion: This study revealed that the rs2088885 and rs7627954 SNPs of TNIK are associated with risperidone treatment response.
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