Journal
PHARMACEUTICAL CHEMISTRY JOURNAL
Volume 56, Issue 5, Pages 583-586Publisher
SPRINGER
DOI: 10.1007/s11094-022-02679-y
Keywords
cold atmospheric plasma; plasma-treated solution (PTS); doxorubicin; gestagen; TGF-beta
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The combined effects of cold-plasma-treated solution of doxorubicin and MPA on TGF-beta production were studied, indicating a dual effect of hydrogen peroxide and nitrite ions formed in the solution. Short treatment decreased the effects, while longer treatment enhanced the effects of the drugs.
Combined effects of a cold-plasma-treated solution of the cytostatic drug doxorubicin and the gestagen medroxyprogesterone acetate (MPA) were studied with respect to their influence on the production of transforming growth factor beta (TGF-beta), which is capable of controlling proliferative processes. Hydrogen peroxide and nitrite ions were formed in cold-plasma-treated Hanks solution. This decreased the effects of doxorubicin and the gestagen on TGF-beta production in human mononuclear leukocytes for short treatment periods (2.5 - 5 min) and increased these effects upon treatment for a longer time (similar to 7.5 min). This phenomenon could be related to a specific influence of hydrogen peroxide at various concentrations in the presence of nitrite ions, doxorubicin, and MPA. Hanks solution treated for a short time with cold plasma could be tested to reduce side effects of doxorubicin (cardiomyopathy) and enhance the antitumor activity of MPA.
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