The power of cross-indication testing: agrochemicals originally stemming from a different indication

Cross-indication testing is the assaying of final compounds, but also their intermediates or side products, from one agrochemical indication against target species of other product lines. This approach has proven to be a highly successful source of lead compounds, which led to several important crop protection products. This review article describes, which herbicides came from fungicides and insecticides, how fungicides have been obtained from herbicide and insecticide leads and which insecticides have their roots in herbicide and fungicide chemistry. (c) 2022 Society of Chemical Industry.

Automated summary

Cross-indication testing is a successful approach to identify lead compounds by assaying the effects of agrochemical compounds, including intermediates and side products, from one indication on target species of other product lines. This review article provides examples of herbicides derived from fungicides and insecticides, fungicides obtained from herbicide and insecticide leads, and insecticides rooted in herbicide and fungicide chemistry.