Journal
PEDIATRIC HEMATOLOGY AND ONCOLOGY
Volume 40, Issue 2, Pages 131-146Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08880018.2022.2085830
Keywords
Inborn errors of immunity; investigation; malignancy; pediatric; primary immunodeficiency
Categories
Ask authors/readers for more resources
This article discusses the causes and complications of inborn errors of immunity (IEI) and emphasizes the importance of recognition of potential IEI by pediatric hemato-oncologists. It provides guidelines for diagnostic tests and treatment options.
Inborn errors of immunity (IEI) are a group of disorders caused by genetically determined defects in the immune system, leading to infections, autoimmunity, autoinflammation and an increased risk of malignancy. In some cases, a malignancy might be the first sign of an underlying IEI. As therapeutic strategies might be different in these patients, recognition of the underlying IEI by the pediatric hemato-oncologist is important. This article, written by a group of experts in pediatric immunology, hemato-oncology, pathology and genetics, aims to provide guidelines for pediatric hemato-oncologists on how to recognize a possible underlying IEI and what diagnostic tests can be performed, and gives some consideration to treatment possibilities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available